Patents
US 12565643 B2: Alpha-galactosidase protein for enzyme replacement therapy (ERT) and methods of use
- Granted
- 2026-03-03
- Filed
- 2020-09-18 application 17640246
- Type
- Utility · 5 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides less immunogenic mutant α-galactosidase A protein (α-gal), methods of making and methods of use. The less immunogenic mutant α-gal of the present invention provides a reduced immune response when administered to a subject.
Source: PTBLXML, file of 2026-03-03 (ipgb20260303.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Medical College of Wisconsin, Inc. 153 patents | US company or organization | Milwaukee, WI | THE MEDICAL COLLEGE OF WISCONSIN INC Nonprofit EXACT high confidence: identical full name and state Medical College of Wisconsin College or university FUZZY medium confidence: same name (governing-board words and legal endings aside) and state MEDICAL COLLEGE OF WISCONSIN Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state | PTBLXML, file of 2026-03-03 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jeffrey A. Medin | Shorewood, WI | 17 | PTBLXML, file of 2026-03-03 | |
| Simone Scalia | Milwaukee, WI | PTBLXML, file of 2026-03-03 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/2465 | PTBLXML, file of 2026-03-03 |
| C12Y | Enzymes | C12Y302/01022 | PTBLXML, file of 2026-03-03 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/00 | PTBLXML, file of 2026-03-03 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-03-04 | Assignment Assignment of assignor's interest | MEDIN, JEFFREY A. signed 2022-02-14 SCALIA, SIMONE signed 2022-02-28 | THE MEDICAL COLLEGE OF WISCONSIN, INC. MILWAUKEE, WI | 59176/458 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.