Patents
US 12562237 B2: Methods and systems for detection and phasing of complex genetic variants
- Granted
- 2026-02-24
- Filed
- 2021-05-19 application 17324793
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed are methods, systems and computer-program products for the determination of complex genetic variants. The disclosed methods, systems and computer-program products may include obtaining a mutant scaffold nucleotide sequence that comprises a sequence that includes mutations characteristic of the complex genetic variant; obtaining a wild-type scaffold nucleotide sequence having a wild-type sequence; generating an alignment of at least one sequence from the sample to the mutant scaffold and to the wild-type scaffold; and determining that the sample contains a mutation characteristic of the complex genetic variant based on alignment to the mutant scaffold and not the wild-type scaffold.
Source: PTBLXML, file of 2026-02-24 (ipgb20260224.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Laboratory Corporation of America Holdings 128 patents | US company or organization | Burlington, NC | PTBLXML, file of 2026-02-24 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Qiandong Zeng | Burlington, NC | PTBLXML, file of 2026-02-24 | ||
| Natalia Tszine Leach | Burlington, NC | PTBLXML, file of 2026-02-24 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G16B | Bioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology | G16B30/00 | PTBLXML, file of 2026-02-24 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6874 | PTBLXML, file of 2026-02-24 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-01-21 | Assignment Assignment of assignor's interest | ZENG, QIANDONG signed 2021-06-08 LEACH, NATALIA TSZINE signed 2021-06-18 | LABORATORY CORPORATION OF AMERICA HOLDINGS BURLINGTON, NC | 73532/579 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.