Patents
US 12522877 B2: Early detection of drug-resistant mycobacterium tuberculosis
- Granted
- 2026-01-13
- Filed
- 2021-06-17 application 17351005
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention relates to oligonucleotides, methods, and kits for detecting an antibiotic-resistant subpopulation within a heteroresistant population of Mycobacterium tuberculosis in a sample. An amplicon of a target locus is obtained from the sample. The target locus comprises a region of interest which comprises one or more minor variants associated with the antibiotic resistance. The target locus is selected from the group consisting of: Rv0678, pepQ, atpE, ddn, fbiA, fbiB, fbiC, fgd, fgd1, and fgd2. The region of interest is interrogated to detect the one or more minor variants and thus, the antibiotic-resistant subpopulation of M. tuberculosis.
Source: PTBLXML, file of 2026-01-13 (ipgb20260113.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Translational Genomics Research Institute 123 patents | US company or organization | Phoenix, AZ | Translational Genomics Research Institute State business registration FUZZY medium confidence: same name (legal endings aside) and state TRANSLATIONAL GENOMICS RESEARCH INSTITUTE Federal lobbying client FUZZY medium confidence: same name (legal endings aside) and state TRANSLATIONAL GENOMICS RESEARCH INSTITUTE Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PTBLXML, file of 2026-01-13 |
| The Regents of the University of California for and on behalf of the San Francisco campus | US company or organization | San Francisco, CA | PTBLXML, file of 2026-01-13 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| David Engelthaler | Phoenix, AZ | 32 | PTBLXML, file of 2026-01-13 | |
| Christopher Allender | Phoenix, AZ | PTBLXML, file of 2026-01-13 | ||
| James Schupp | Phoenix, AZ | PTBLXML, file of 2026-01-13 | ||
| John Metcalfe | San Francisco, CA | PTBLXML, file of 2026-01-13 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/689 | PTBLXML, file of 2026-01-13 |
| G16B | Bioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology | G16B20/20 | PTBLXML, file of 2026-01-13 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.