Patents
US 12503439 B2: Heteroaryl compounds for the treatment of pain
- Granted
- 2025-12-23
- Filed
- 2023-04-21 application 18137939
- Type
- Utility · 35 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compounds, and pharmaceutically acceptable salts thereof, useful as inhibitors of sodium channels are provided. Also provided are pharmaceutical compositions comprising the compounds or pharmaceutically acceptable salts and methods of using the compounds, pharmaceutically acceptable salts, and pharmaceutical compositions in the treatment of various disorders, including pain.
Source: PVGPATDIS, file of 2026-04-10 (ipg251223.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Mark Miller | Rancho Santa Fe, CA | 97 | PVGPATDIS, file of 2026-04-10 | |
| Dennis James Hurley | San Marcos, CA | 40 | PVGPATDIS, file of 2026-04-10 | |
| Timothy Neubert | San Diego, CA | 24 | PVGPATDIS, file of 2026-04-10 | |
| Vijayalaksmi Arumugam | San Marcos, CA | 40 | PVGPATDIS, file of 2026-04-10 | |
| Sara S. Hadida Ruah | Village of La Jolla, CA | 86 | PVGPATDIS, file of 2026-04-10 | |
| Jason McCartney | Cardiff-by-the-Sea, CA | 73 | PVGPATDIS, file of 2026-04-10 | |
| Jinglan Zhou | San Diego, CA | 99 | PVGPATDIS, file of 2026-04-10 | |
| Jaclyn Chau | San Diego, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Robert Martin Demoret | San Diego, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Senait G. Ghirmai | San Diego, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Roman A. Valiulin | San Diego, CA | 10 | PVGPATDIS, file of 2026-04-10 | |
| Alexander Fredrick Kintzer | Carlsbad, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| David Robert Slochower | San Diego, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Kathleen Aertgeerts | San Diego, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Elizabeth Mary Beck | Abingdon, GB | 27 | PVGPATDIS, file of 2026-04-10 | |
| James Jun Bon Mui | Watford, GB | 1 | PVGPATDIS, file of 2026-04-10 | |
| Miranda Adele Wright | North Hinksey, GB | 1 | PVGPATDIS, file of 2026-04-10 | |
| Ronald Knegtel | Abingdon, GB | 79 | PVGPATDIS, file of 2026-04-10 | |
| Ewa Iwona Chudyk | Wantage, GB | 8 | PVGPATDIS, file of 2026-04-10 | |
| Joanne Pinder | East Hagbourne, GB | 49 | PVGPATDIS, file of 2026-04-10 | |
| James Dodd | Wallingford, GB | 6 | PVGPATDIS, file of 2026-04-10 | |
| Iain Simpson | North Hinksey, GB | 24 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P9/06 | PVGPATDIS, file of 2026-04-10 |
| C07D | Heterocyclic compounds | C07D215/233 | PVGPATDIS, file of 2026-04-10 |
| C07B | General methods of organic chemistry; apparatus therefor | C07B2200/05 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-12-19 | Assignment Assignment of assignor's interest | KINTZER, ALEXANDER FREDERICK signed 2024-12-11 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 69637/132 | ECORSEXC, file of 2026-09-25 |
| 2023-09-18 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (EUROPE) LIMITED signed 2023-09-14 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 64931/815 | ECORSEXC, file of 2026-09-25 |
| 2023-09-18 | Assignment Assignment of assignor's interest | SIMPSON, IAIN signed 2023-07-04 | VERTEX PHARMACEUTICALS (EUROPE) LIMITED LONDON | 64931/459 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC signed 2023-04-19 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63910/278 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (EUROPE) LIMITED signed 2023-04-19 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63910/57 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | MILLER, MARK THOMAS signed 2023-04-18 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 63910/25 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | BECK, ELIZABETH MARY signed 2023-04-19 CHUDYK, EWA IWONA signed 2023-04-19 KNEGTEL, RONALD MARCELLUS ALPHONSUS signed 2023-04-19 MUI, JAMES JUN BON signed 2023-04-19 PINDER, JOANNE LOUISE signed 2023-04-19 WRIGHT, MIRANDA ADELE signed 2023-04-19 | VERTEX PHARMACEUTICALS (EUROPE) LIMITED LONDON | 63909/626 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | DODD, JAMES signed 2023-04-19 | VERTEX PHARMACEUTICALS (EUROPE) LIMITED LONDON | 63909/569 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | ARUMUGAM, VIJAYALAKSMI signed 2023-04-13 HADIDA RUAH, SARA SABINA signed 2023-04-13 MCCARTNEY, JASON signed 2023-04-13 ZHOU, JINGLAN signed 2023-04-13 HURLEY, DENNIS JAMES signed 2023-04-18 NEUBERT, TIMOTHY DONALD signed 2023-04-18 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 63909/511 | ECORSEXC, file of 2026-09-25 |
| 2023-06-09 | Assignment Assignment of assignor's interest | AERTGEERTS, KATHLEEN signed 2023-04-13 CHAU, JACLYN signed 2023-04-13 DEMORET, ROBERT MARTIN signed 2023-04-13 KINTZER, ALEXANDER FREDERIK signed 2023-04-13 SLOCHOWER, DAVID ROBERT signed 2023-04-18 VALIULIN, ROMAN ASKATOVICH signed 2023-04-18 GHIRMAI, SENAIT G. signed 2023-04-19 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 63909/342 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.