Patents
US 12502376 B2: Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD)
- Granted
- 2025-12-23
- Filed
- 2021-04-02 application 17916448
- Type
- Utility · 33 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Pyrano[4,3-b]indole derivatives as alpha-1-antitrypsin modulators for treating alpha-1-antitrypsin deficiency (AATD).
Source: PVGPATDIS, file of 2026-04-10 (ipg251223.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Michael P. Clark | Concord, MA | 16 | PVGPATDIS, file of 2026-04-10 | |
| Simon Giroux | Cambridge, MA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Philip Collier | Hingham, MA | 24 | PVGPATDIS, file of 2026-04-10 | |
| Qing Tang | Boxborough, MA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Nathan D. Waal | Somerville, MA | 29 | PVGPATDIS, file of 2026-04-10 | |
| Sarathy KESAVAN | Quincy, MA | 4 | PVGPATDIS, file of 2026-04-10 | |
| Peter Jones | Sharon, MA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Michael Aaron Brodney | Newton, MA | 58 | PVGPATDIS, file of 2026-04-10 | |
| Wenxin Gu | Concord, MA | 28 | PVGPATDIS, file of 2026-04-10 | |
| Diane Boucher | Beverly, MA | 6 | PVGPATDIS, file of 2026-04-10 | |
| Lev T.D. Fanning | San Marcos, CA | 21 | PVGPATDIS, file of 2026-04-10 | |
| Amy Beth HALL | Wellesley, MA | 4 | PVGPATDIS, file of 2026-04-10 | |
| Dennis James Hurley | San Marcos, CA | 40 | PVGPATDIS, file of 2026-04-10 | |
| Mac Arthur Johnson, Jr. | Derry, NH | 12 | PVGPATDIS, file of 2026-04-10 | |
| John Patrick Maxwell | Hingham, MA | 44 | PVGPATDIS, file of 2026-04-10 | |
| Rebecca Jane Swett | Somerville, MA | 6 | PVGPATDIS, file of 2026-04-10 | |
| Timothy Lewis TAPLEY | Irvine, CA | 6 | PVGPATDIS, file of 2026-04-10 | |
| Stephen Andrew Thomson | Durham, NC | 16 | PVGPATDIS, file of 2026-04-10 | |
| Veronique Damagnez | Framingham, MA | 7 | PVGPATDIS, file of 2026-04-10 | |
| Kevin Michael Cottrell | Cambridge, MA | 47 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/407 | PVGPATDIS, file of 2026-04-10 |
| C07D | Heterocyclic compounds | C07D491/04 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-12-28 | Assignment Assignment of assignor's interest | FANNING, LEV T.D. signed 2021-03-10 HURLEY, DENNIS JAMES signed 2021-03-10 TAPLEY, TIMOTHY LEWIS signed 2021-03-10 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 65973/611 | ECORSEXC, file of 2026-09-25 |
| 2023-12-28 | Assignment Assignment of assignor's interest | CLARK, MICHAEL PHILIP signed 2021-03-10 WAAL, NATHAN D. signed 2021-03-10 COLLIER, PHILIP NOEL signed 2021-03-11 GU, WENXIN signed 2021-03-11 BOUCHER, DIANE MARIE signed 2021-03-15 BRODNEY, MICHAEL AARON signed 2021-03-15 JONES, PETER signed 2021-03-15 DAMAGNEZ, VERONIQUE signed 2021-03-17 SWETT, REBECCA JANE signed 2021-03-21 COTTRELL, KEVIN MICHAEL signed 2021-03-22 GIROUX, SIMON signed 2021-03-22 HALL, AMY B. signed 2021-03-22 THOMSON, STEPHEN A. signed 2021-03-22 MAXWELL, JOHN PATRICK signed 2021-03-23 KESAVAN, SARATHY signed 2021-03-24 TANG, QING signed 2021-03-24 JOHNSON, MAC ARTHUR, JR. signed 2021-03-29 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 65973/515 | ECORSEXC, file of 2026-09-25 |
| 2023-12-28 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC signed 2021-03-16 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 65973/456 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.