Patents
US 12497627 B2: BZIP transcription factors regulate conversion of nicotine to nornicotine
- Granted
- 2025-12-16
- Filed
- 2023-09-07 application 18243312
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method of decreasing conversion of nicotine to nornicotine is provided herein. The methods includes administering at least one basic region/leucine zipper (bZIP) type transcription factor inhibitor to an organism in need thereof. Also provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a bZIP type transcription factor binding site on a promoter of a nicotine N-demethylase (NND). Further provided herein is a method of decreasing conversion of nicotine to nornicotine including mutating a plant genome to knockout at least one bZIP type transcription factor.
Source: PVGPATDIS, file of 2026-04-10 (ipg251216.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION 446 patents | US company or organization | Lexington, KY | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Ling Yuan | Lexington, KY | 5 | PVGPATDIS, file of 2026-04-10 | |
| Sanjay Singh | Lexington, KY | 34 | PVGPATDIS, file of 2026-04-10 | |
| Sitakanta Pattanaik | Lexington, KY | 3 | PVGPATDIS, file of 2026-04-10 | |
| Darlene Madeline Lawson | Kernersville, NC | 13 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/415 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/8218 | PVGPATDIS, file of 2026-04-10 |
| A01H | New plants or ; non-transgenic; processes for obtaining them; plant reproduction by tissue culture techniques | A01H5/12 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-09-12 | Assignment Assignment of assignor's interest | SING, SANJAY K signed 2017-12-08 YUAN, LING signed 2017-12-08 PATTANAIK, SITAKANTA signed 2017-12-10 | UNIVERSITY OF KENTUCKY RESEARCH FOUNDATION LEXINGTON, KY | 65489/960 | ECORSEXC, file of 2026-09-25 |
| 2023-09-12 | Assignment Assignment of assignor's interest | LAWSON, DARLENE MADELINE signed 2018-04-12 | R.J. REYNOLDS TOBACCO COMPANY WINSTON-SALEM, NC | 64876/667 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.