Patents
US 12497614 B2: Compositions and methods for editing beta-globin for treatment of hemaglobinopathies
- Granted
- 2025-12-16
- Filed
- 2021-12-17 application 17554682
- Type
- Utility · 24 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The disclosure features systems and methods for correcting a mutation in the human beta-globin (HBB) gene in a cell or population of cells. The disclosure also features methods of increasing repair of a DNA double stranded break (DSB) in an HBB gene by the homology-directed repair (HDR) pathway. The disclosure also features compositions for use in the methods.
Source: PVGPATDIS, file of 2026-04-10 (ipg251216.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Sanjay D'SOUZA | Cambridge, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Jason West | Lexington, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Brenda Eustace | Boston, MA | 4 | PVGPATDIS, file of 2026-04-10 | |
| Sudipta Mahajan | Boston, MA | 4 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/11 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K40/10 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P7/06 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-06-07 | Correction Corrective assignment to correct the error in the name of the assignee previously recorded on reel 059895 frame 0174. assignor(s) hereby confirms the assignment. | CRISPR THERAPEUTICS AG signed 2022-05-09 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 64055/834 | ECORSEXC, file of 2026-09-25 |
| 2022-05-11 | Assignment Assignment of assignor's interest | CRISPR THERAPEUTICS AG signed 2022-05-09 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 59895/174 | ECORSEXC, file of 2026-09-25 |
| 2022-04-19 | Assignment Assignment of assignor's interest | EUSTACE, BRENDA K. signed 2022-03-15 MAHAJAN, SUDIPTA signed 2022-03-21 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 59639/307 | ECORSEXC, file of 2026-09-25 |
| 2022-04-19 | Assignment Assignment of assignor's interest | D'SOUZA, SANJAY signed 2022-04-08 WEST, JASON signed 2022-04-11 | CRISPR THERAPEUTICS AG ZUG | 59639/194 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.