Patents
US 12492388 B2: Materials and methods for treatment of hemoglobinopathies
- Granted
- 2025-12-09
- Filed
- 2022-01-26 application 17585365
- Type
- Utility · 26 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Materials and methods for treating a patient with hemoglobinopathy, both ex vivo and in vivo and materials and methods for deleting at least a portion of a human beta globin locus on chromosome 11 in a human cell by genome editing and thereby increasing the production of fetal hemoglobin (HbF).
Source: PVGPATDIS, file of 2026-04-10 (ipg251209.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Tirtha Chakraborty | Cambridge, MA | 45 | PVGPATDIS, file of 2026-04-10 | |
| Bibhu Prasad Mishra | Wakefield, MA | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/22 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/395 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P7/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-01-28 | Assignment Assignment of assignor's interest | CRISPR THERAPEUTICS AG signed 2019-08-21 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 58801/497 | ECORSEXC, file of 2026-09-25 |
| 2022-01-28 | Assignment Assignment of assignor's interest | CHAKRABORTY, TIRTHA signed 2018-03-23 MISHRA, BIBHU PRASAD signed 2018-05-04 | CRISPR THERAPEUTICS AG ZUG | 58801/485 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.