Patents
US 12486528 B2: Compositions and methods for measuring and inhibiting calpain-5 activity
- Granted
- 2025-12-02
- Filed
- 2020-10-09 application 17767280
- Type
- Utility · 5 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compositions, methods, and kits are provided for assaying calpain-5 activity and inhibition. In particular, novel peptide substrates are provided for detecting calpain-5, measuring calpain-5 activity, and screening for inhibitors of calpain-5 to identify potential therapeutic agents for treating retinal diseases and other diseases associated with calpain-5 hyperactivity. Additionally, novel inhibitors of calpain-5 are also provided.
Source: PVGPATDIS, file of 2026-04-10 (ipg251202.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Board of Trustees of the Leland Stanford Junior University 3,100 patents | US company or organization | Stanford, CA | Stanford University College or university EXACT high confidence: through the nonprofit with the college's EIN (identical full name and state) THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| University of Iowa Research Foundation 401 patents | US company or organization | Iowa City, IA | UNIVERSITY OF IOWA RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| The United States Government as Represented by the Department of Veterans Affairs 347 patents | US federal government | Washington, DC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Vinit Mahajan | Redwood City, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Gabriel Velez | Palo Alto, CA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Young Joo Sun | Redwood City, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Kellie A Schaefer | Redwood City, CA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Alexander G Bassuk | Iowa City, IA | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/8139 | PVGPATDIS, file of 2026-04-10 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/37 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K45/06 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P27/02 | PVGPATDIS, file of 2026-04-10 |
| C12Y | Enzymes | C12Y304/22 | PVGPATDIS, file of 2026-04-10 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N2333/96466 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-08-16 | Government interest Confirmatory license | STANFORD UNIVERSITY signed 2023-08-02 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 64605/730 | ECORSEXC, file of 2026-09-25 |
| 2023-01-05 | Correction Corrective assignment to correct the second assignee" the united states government as represented by the department of veterans affairs" to be added. previously recorded at reel: 061812 frame: 0807. assignor(s) hereby confirms the assignment of | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY signed 2021-11-18 | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS WASHINGTON, DC THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY STANFORD, CA | 62386/879 | ECORSEXC, file of 2026-09-25 |
| 2022-11-17 | Assignment Assignment of assignor's interest | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY signed 2021-11-18 | THE UNITED STATES GOVERNMENT AS REPRESENTED BY THE DEPARTMENT OF VETERANS AFFAIRS WASHINGTON, DC | 61812/807 | ECORSEXC, file of 2026-09-25 |
| 2022-11-17 | Assignment Assignment of assignor's interest | BASSUK, ALEXANDER G signed 2020-12-28 | UNIVERSITY OF IOWA RESEARCH FOUNDATION IOWA CITY, IA | 61812/799 | ECORSEXC, file of 2026-09-25 |
| 2022-11-17 | Assignment Assignment of assignor's interest | SCHAEFER, KELLIE A signed 2020-12-20 MAHAJAN, VINIT signed 2020-12-22 SUN, YOUNG JOO signed 2020-12-22 VELEZ, GABRIEL signed 2020-12-22 | THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY STANFORD, CA | 61812/662 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.