Patents
US 12482105 B2: Systems and methods for single molecule quantification
- Granted
- 2025-11-25
- Filed
- 2022-01-14 application 17576867
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A method for quantifying labels on a substrate is performed by an electronic device with one or more processors and memory. The method includes obtaining digital data corresponding to a multi-dimensional measurement over the substrate; identifying a first set of sub-portions of the digital data; and, for a respective sub-portion of the first set of sub-portions of the digital data: increasing a quantity of labels, and subtracting a reference signal distribution from the respective sub-portion to obtain subtracted sub-portion data. The method also includes obtaining subtracted digital data. The subtracted digital data includes the subtracted sub-portion data for the respective sub-portion. The method further includes identifying a second set of one or more sub-portions of the subtracted digital data; and, for a respective sub-portion of the second set of one or more sub-portions of the subtracted digital data, increasing a quantity of labels.
Source: PVGPATDIS, file of 2026-04-10 (ipg251125.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Laboratory Corporation of America Holdings 128 patents | US company or organization | Burlington, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Hywel Bowden Jones | Seattle, WA | 8 | PVGPATDIS, file of 2026-04-10 | |
| Andrea Lynn McEvoy | Greenbrae, CA | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G06T | Image data processing or generation, in general | G06T7/11 | PVGPATDIS, file of 2026-04-10 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6818 | PVGPATDIS, file of 2026-04-10 |
| G06V | Image or video recognition or understanding | G06V20/69 | PVGPATDIS, file of 2026-04-10 |
| G16B | Bioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology | G16B20/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-08-30 | Assignment Assignment of assignor's interest | INVITAE CORPORATION signed 2024-08-05 | LABORATORY CORPORATION OF AMERICA HOLDINGS BURLINGTON, NC | 68822/25 | PASDL, file of 2026-10-15 |
| 2023-03-13 | Security interest Security interest Security interest | INVITAE CORPORATION signed 2023-03-07 | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT ST. PAUL, MN | 63787/148 | PASDL, file of 2026-10-15 |
| 2022-04-14 | Assignment Assignment of assignor's interest | SINGULAR BIO, INC. signed 2021-06-14 | INVITAE CORPORATION SAN FRANCISCO, CA | 59594/180 | ECORSEXC, file of 2026-09-25 |
| 2022-04-14 | Assignment Assignment of assignor's interest | JONES, HYWEL BOWDEN signed 2016-09-26 MCEVOY, ANDREA LYNN signed 2016-09-26 | SINGULAR BIO, INC. SAN FRANCISCO, CA | 59594/170 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.