Patents
US 12454684 B2: Methods using novel CPF1 mutations that enhance the DNA cleavage activity of Acidaminococcus sp. CPF1
- Granted
- 2025-10-28
- Filed
- 2022-07-26 application 17873485
- Type
- Utility · 8 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure concerns polynucleotides and amino acids of Acidaminococcus sp. Cas12a (Cpf1) and methods for their use for genome editing in eukaryotic cells.
Source: PVGPATDIS, file of 2026-04-10 (ipg251028.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| INTEGRATED DNA TECHNOLOGIES, INC. 103 patents | US company or organization | Coralville, IA | INTEGRATED DNA TECHNOLOGIES, INC. State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Liyang Zhang | Coralville, IA | 47 | PVGPATDIS, file of 2026-04-10 | |
| Christopher Anthony Vakulskas | North Liberty, IA | 22 | PVGPATDIS, file of 2026-04-10 | |
| Nicole Mary Bode | Oxford, IA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Michael Allen Collingwood | North Liberty, IA | 19 | PVGPATDIS, file of 2026-04-10 | |
| Kristin Beltz | Cedar Rapids, IA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Mark Aaron Behlke | Coralville, IA | 74 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/22 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-09-17 | Assignment Assignment of assignor's interest | ZHANG, LIYANG signed 2019-11-19 VAKULSKAS, CHRISTOPHER ANTHONY signed 2019-11-19 BODE, NICOLE MARY signed 2019-11-19 COLLINGWOOD, MICHAEL ALLEN signed 2019-11-19 BELTZ, KRISTIN RENEE signed 2019-11-20 BEHLKE, MARK AARON signed 2019-11-20 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 72285/383 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.