Patents
US 12454576 B2: Nanobody based imaging and targeting of ECM in disease and development
- Granted
- 2025-10-28
- Filed
- 2023-02-28 application 18175786
- Type
- Utility · 9 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Methods for developing disease-related nanobodies and related products and kits are provided. The disease-specific proteins are extracellular matrix (ECM) proteins, domains or epitopes that are associated with various aspects of disease and are not present, or are present in very low quantities, in non-diseased individuals. Highly effective nanobodies capable of specifically binding to these ECM protein epitopes useful in in vivo imaging assays, the detection, diagnosis and treatment of diseases as well as monitoring therapeutic progress in a patient with a disease are provided herein.
Source: PVGPATDIS, file of 2026-04-10 (ipg251028.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY 5,106 patents | US company or organization | Cambridge, MA | Massachusetts Institute of Technology College or university EXACT high confidence: identical full name and state MASSACHUSETTS INSTITUTE OF TECHNOLOGY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Children's Medical Center Corporation 717 patents | US company or organization | Boston, MA | THE CHILDREN'S MEDICAL CENTER CORPORATION State business registration FUZZY medium confidence: same name (legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| Whitehead Institute for Biomedical Research 176 patents | US company or organization | Cambridge, MA | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Richard O. Hynes | Winchester, MA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Noor Jailkhani | Cambridge, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Hidde L. Ploegh | Boston, MA | 25 | PVGPATDIS, file of 2026-04-10 | |
| Yushu J. Xie | Brookline, MA | 4 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/2842 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K40/11 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/04 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0636 | PVGPATDIS, file of 2026-04-10 |
| B82Y | Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | B82Y5/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-04-26 | Assignment Assignment of assignor's interest | HYNES, RICHARD O. signed 2017-08-10 | HOWARD HUGHES MEDICAL INSTITUTE CHEVY CHASE, MD | 67236/602 | ECORSEXC, file of 2026-09-25 |
| 2024-04-26 | Assignment Assignment of assignor's interest | XIE, YUSHU JOY signed 2020-07-12 | CHILDREN'S MEDICAL CENTER CORPORATION BOSTON, MA MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 67236/597 | ECORSEXC, file of 2026-09-25 |
| 2024-04-26 | Assignment Assignment of assignor's interest | PLOEGH, HIDDE L. signed 2020-07-16 | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH CAMBRIDGE, MA CHILDREN'S MEDICAL CENTER CORPORATION BOSTON, MA | 67236/592 | ECORSEXC, file of 2026-09-25 |
| 2024-04-26 | Assignment Assignment of assignor's interest | HOWARD HUGHES MEDICAL INSTITUTE signed 2019-01-31 HYNES, RICHARD O. signed 2019-01-31 JAILKHANI, NOOR signed 2019-01-31 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 67236/549 | ECORSEXC, file of 2026-09-25 |
| 2023-04-19 | Government interest Confirmatory license | MASSASSCHUSETTS INSTITUTE OF TECHNOLOGY signed 2023-04-17 | UNITED STATES GOVERNMENT FORT DETRICK, MD | 63379/228 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.