Patents
US 12447142 B2: Compositions and methods for preventing and treating radiation-induced bystander effects caused by radiation or radiotherapy
- Granted
- 2025-10-21
- Filed
- 2022-06-29 application 17852475
- Type
- Utility · 7 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention provides novel compositions and methods for the treatment of Radiation-Induced Bystander Effects (RIBE), resulting from radiation exposure. In one preferred embodiment the inventions includes novel therapeutic agents, including but not limited to quercetin and quercetin analogs, as well as E64, CA074, CA074Me, that interfere with the activity of Cathepsin B.
Source: PVGPATDIS, file of 2026-04-10 (ipg251021.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Regents of the University of Colorado 307 patents | US company or organization | Denver, CO | THE REGENTS OF THE UNIVERSITY OF COLORADO Federal lobbying client EXACT high confidence: identical full name and state REGENTS OF THE UNIVERSITY OF COLORADO Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Ding Xue | Louisville, CO | 6 | PVGPATDIS, file of 2026-04-10 | |
| Yu Peng | 龙王头村, CN | 6 | PVGPATDIS, file of 2026-04-10 | |
| Man Zhang | Beijing, CN | 31 | PVGPATDIS, file of 2026-04-10 | |
| Lingjun Zheng | Boulder, CO | 2 | PVGPATDIS, file of 2026-04-10 | |
| Qian Liang | Beijing, CN | 17 | PVGPATDIS, file of 2026-04-10 | |
| Hanzeng Li | Louisville, CO | 2 | PVGPATDIS, file of 2026-04-10 | |
| Jau-Song Yu | Taoyuan, TW | 7 | PVGPATDIS, file of 2026-04-10 | |
| Jeng-Ting Chen | Taoyuan, TW | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/352 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P17/16 | PVGPATDIS, file of 2026-04-10 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6886 | PVGPATDIS, file of 2026-04-10 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/575 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-03-12 | Assignment Assignment of assignor's interest | LIANG, QIAN signed 2022-02-15 PENG, YU signed 2022-02-15 ZHANG, MAN signed 2022-02-15 | TSINGHUA UNIVERSITY BEIJING | 70490/578 | ECORSEXC, file of 2026-09-25 |
| 2025-03-12 | Assignment Assignment of assignor's interest | CHEN, JENG TING signed 2021-12-23 YU, JAU-SONG signed 2021-12-24 | CHANG GUNG UNIVERSITY TAOYUAN | 70490/525 | ECORSEXC, file of 2026-09-25 |
| 2025-03-12 | Assignment Assignment of assignor's interest | LI, HANZENG signed 2018-09-05 XUE, DING signed 2022-05-04 ZHENG, LINGJUN signed 2022-05-08 | THE REGENTS OF THE UNIVERSITY OF COLORADO, A BODY CORPORATE DENVER, CO | 70490/361 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.