Patents
US 12428488 B2: Engineering of an antibody for tumor-selective binding of CD47
- Granted
- 2025-09-30
- Filed
- 2020-04-03 application 17594131
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Antibodies are provided which comprise at least one Fab portion that binds CD47 and at least one Fab portion that binds the tumor associated antigen (TAA) CD20; wherein the Fab portion that binds CD47 exhibits low affinity for CD47; and, wherein the Fab portion that binds CD20 exhibits high affinity for CD20; and, wherein the antibody selectively binds CD47 and blocks CD47 interaction with SIRPĪ± in tumor cells while exhibiting no substantial binding to CD47 in normal cells.
Source: PVGPATDIS, file of 2026-04-10 (ipg250930.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Celgene Corporation 413 patents | US company or organization | Summit, NJ | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Haralambos HADJIVASSILIOU | Summit, NJ | 3 | PVGPATDIS, file of 2026-04-10 | |
| Dan ZHU | Summit, NJ | 2 | PVGPATDIS, file of 2026-04-10 | |
| Jeonghoon Sun | Summit, NJ | 42 | PVGPATDIS, file of 2026-04-10 | |
| Sharmistha ACHARYA | Summit, NJ | 2 | PVGPATDIS, file of 2026-04-10 | |
| Jeffrey C. Johnson | Summit, NJ | 4 | PVGPATDIS, file of 2026-04-10 | |
| Henry Hin Lee Chan | Summit, NJ | 18 | PVGPATDIS, file of 2026-04-10 | |
| Kandasamy Hariharan | Summit, NJ | 9 | PVGPATDIS, file of 2026-04-10 | |
| Ho Sung Cho | Summit, NJ | 28 | Person page FUZZY medium confidence | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/02 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K16/2887 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K2039/505 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-07-08 | Assignment Assignment of assignor's interest | SUN, JEONGHOON signed 2020-03-26 ZHU, DAN signed 2020-03-26 JOHNSON, JEFFREY signed 2020-03-27 CHO, HO signed 2020-03-30 ACHARYA, SHARMISTHA signed 2020-03-31 CHAN, HENRY signed 2020-03-31 HADJIVASSILIOU, HARALAMBOS signed 2020-03-31 HARIHARAN, KANDASAMY signed 2020-04-01 | CELGENE CORPORATION SUMMIT, NJ | 60616/706 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.