Patents
US 12421251 B2: Cystic fibrosis transmembrane conductance regulator modulating agents
- Granted
- 2025-09-23
- Filed
- 2020-04-02 application 17600829
- Type
- Utility · 25 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compound (I), deuterated derivatives, and pharmaceutically acceptable salts of any of the foregoing are disclosed. Methods of treating cystic fibrosis using these compounds are also disclosed.
Source: PVGPATDIS, file of 2026-04-10 (ipg250923.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Vertex Pharmaceuticals Incorporated 764 patents | US company or organization | Boston, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Alexander Russell Abela | Escondido, CA | 10 | PVGPATDIS, file of 2026-04-10 | |
| Sunny Abraham | San Diego, CA | 18 | PVGPATDIS, file of 2026-04-10 | |
| Corey Anderson | Watertown, MA | 55 | PVGPATDIS, file of 2026-04-10 | |
| Vijayalaksmi Arumugam | San Marcos, CA | 40 | PVGPATDIS, file of 2026-04-10 | |
| Jaclyn Chau | San Diego, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Jeremy J. Clemens | San Diego, CA | 21 | PVGPATDIS, file of 2026-04-10 | |
| Thomas Cleveland | San Marcos, CA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Timothy A. DWIGHT | Quincy, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Bryan A. Frieman | Village of La Jolla, CA | 28 | PVGPATDIS, file of 2026-04-10 | |
| Peter Diederik Jan Grootenhuis | Del Mar, CA | 69 | PVGPATDIS, file of 2026-04-10 | |
| Sara S. Hadida Ruah | Village of La Jolla, CA | 86 | PVGPATDIS, file of 2026-04-10 | |
| Yoshihiro ISHIHARA | San Diego, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Paul Krenitsky | San Francisco, CA | 23 | PVGPATDIS, file of 2026-04-10 | |
| Jason McCartney | Cardiff-by-the-Sea, CA | 73 | PVGPATDIS, file of 2026-04-10 | |
| Vito Melillo | Escondido, CA | 11 | PVGPATDIS, file of 2026-04-10 | |
| Mark Miller | Rancho Santa Fe, CA | 97 | PVGPATDIS, file of 2026-04-10 | |
| Alina Silina | Needham, MA | 22 | PVGPATDIS, file of 2026-04-10 | |
| Johnny Uy | San Diego, CA | 23 | PVGPATDIS, file of 2026-04-10 | |
| Jinglan Zhou | San Diego, CA | 99 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D515/08 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P11/00 | PVGPATDIS, file of 2026-04-10 |
| C07B | General methods of organic chemistry; apparatus therefor | C07B2200/05 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-09-08 | Assignment Assignment of assignor's interest | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC signed 2020-05-14 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 61025/254 | ECORSEXC, file of 2026-09-25 |
| 2022-09-08 | Assignment Assignment of assignor's interest | GROOTENHUIS, PETER signed 2002-10-22 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 61025/231 | ECORSEXC, file of 2026-09-25 |
| 2022-09-08 | Assignment Assignment of assignor's interest | MCCARTNEY, JASON signed 2020-03-20 MELILLO, VITO signed 2020-03-20 CHAU, JACLYN signed 2020-03-23 ABELA, ALEXANDER RUSSELL signed 2020-03-24 ISHIHARA, YOSHIHIRO signed 2020-03-24 ANDERSON, COREY DON signed 2020-03-25 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 61025/213 | ECORSEXC, file of 2026-09-25 |
| 2022-09-08 | Assignment Assignment of assignor's interest | MILLER, MARK THOMAS signed 2020-03-20 CLEVELAND, THOMAS signed 2020-03-22 CLEMENS, JEREMY signed 2020-03-23 SILINA, ALINA signed 2020-03-23 ARUMUGAM, VIJAYALAKSMI signed 2020-03-24 HADIDA RUAH, SARA SABINA signed 2020-03-24 ZHOU, JINGLAN signed 2020-03-25 UY, JOHNNY signed 2020-03-26 FRIEMAN, BRYAN A. signed 2020-03-30 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 61025/104 | ECORSEXC, file of 2026-09-25 |
| 2022-09-08 | Assignment Assignment of assignor's interest | DWIGHT, TIMOTHY A. signed 2020-03-28 | VERTEX PHARMACEUTICALS INCORPORATED BOSTON, MA | 61025/100 | ECORSEXC, file of 2026-09-25 |
| 2022-09-08 | Assignment Assignment of assignor's interest | ABRAHAM, SUNNY signed 2020-03-31 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 61025/96 | ECORSEXC, file of 2026-09-25 |
| 2022-09-08 | Assignment Assignment of assignor's interest | KRENITSKY, PAUL signed 2020-03-30 | VERTEX PHARMACEUTICALS (SAN DIEGO) LLC SAN DIEGO, CA | 61025/79 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.