Patents
US 12419940 B2: Compositions and methods for modified dendrimer nanoparticle delivery
- Granted
- 2025-09-23
- Filed
- 2021-03-10 application 17198037
- Type
- Utility · 23 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compositions and methods for modified dendrimer nanoparticle (“MDNP”) delivery of therapeutic, prophylactic and/or diagnostic agent such as large repRNA molecules to the cells of a subject have been developed. MDNPs efficiently drive proliferation of antigen-specific T cells against intracellular antigen, and potentiate antigen-specific antibody responses. MDNPs can be multiplexed to deliver two or more different repRNAs to modify expression kinetics of encoded antigens and to simultaneous deliver repRNAs and mRNAs including the same UTR elements that promote expression of encoded antigens.
Source: PVGPATDIS, file of 2026-04-10 (ipg250923.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY 5,106 patents | US company or organization | Cambridge, MA | Massachusetts Institute of Technology College or university EXACT high confidence: identical full name and state MASSACHUSETTS INSTITUTE OF TECHNOLOGY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Whitehead Institute for Biomedical Research 176 patents | US company or organization | Cambridge, MA | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Omar Khan | Cambridge, MA | 6 | PVGPATDIS, file of 2026-04-10 | |
| Jasdave Chahal | Arlington, MA | 6 | PVGPATDIS, file of 2026-04-10 | |
| Daniel Griffith Anderson | Cambridge, MA | 112 | PVGPATDIS, file of 2026-04-10 | |
| Hidde L. Ploegh | Brookline, MA | 25 | PVGPATDIS, file of 2026-04-10 | |
| Robert S. Langer | Cambridge, MA | 291 | PVGPATDIS, file of 2026-04-10 | |
| Tyler E. Jacks | Cambridge, MA | 8 | PVGPATDIS, file of 2026-04-10 | |
| David A. Canner | Cambridge, MA | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/0012 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P31/00 | PVGPATDIS, file of 2026-04-10 |
| B82Y | Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | B82Y5/00 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/87 | PVGPATDIS, file of 2026-04-10 |
| Y02A | Technologies for adaptation to climate change | Y02A50/30 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-06-07 | Assignment Assignment of assignor's interest | PLOEGH, HIDDE signed 2016-10-18 CHAHAL, JASDAVE S. signed 2017-06-09 | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH CAMBRIDGE, MA | 56451/939 | ECORSEXC, file of 2026-09-25 |
| 2021-06-07 | Assignment Assignment of assignor's interest | CANNER, DAVID A. signed 2017-05-23 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56451/911 | ECORSEXC, file of 2026-09-25 |
| 2021-06-07 | Assignment Assignment of assignor's interest | HOWARD HUGHES MEDICAL INSTITUTE signed 2017-05-22 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56451/890 | ECORSEXC, file of 2026-09-25 |
| 2021-06-07 | Assignment Assignment of assignor's interest | JACKS, TYLER E. signed 2017-05-04 | HOWARD HUGHES MEDICAL INSTITUTE CHEVY CHASE, MD | 56451/794 | ECORSEXC, file of 2026-09-25 |
| 2021-06-07 | Assignment Assignment of assignor's interest | KHAN, OMAR F. signed 2016-05-24 LANGER, ROBERT S. signed 2017-10-19 ANDERSON, DANIEL G. signed 2017-12-21 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 56451/654 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.