Patents
US 12405253 B2: Methods and systems for hydrophilic-phase extraction
- Granted
- 2025-09-02
- Filed
- 2022-12-30 application 18148839
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Disclosed herein are embodiments of methods for oligonucleotide analysis using a novel solid-phase extraction and hydrophilic-interaction liquid chromatography. The unique polar-based retention methods provided herein provide a high-recovery extraction. The methods improve assay reliability and reproducibility and reach picomolar sensitivity with the demonstrably beneficial accurate mass platform. Also disclosed herein are systems and computer program products for performing these methods.
Source: PVGPATDIS, file of 2026-04-10 (ipg250902.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Laboratory Corporation of America Holdings 128 patents | US company or organization | Burlington, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Robert MacNeill | Hoffman, NJ | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N30/06 | PVGPATDIS, file of 2026-04-10 |
| B01D | Separation | B01D15/305 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-09-04 | Correction Corrective assignment to correct the inventors legal name is robert macneill previously recorded on reel 67902 frame 368. assignor(s) hereby confirms the assignment. | MACNEILL, ROBERT signed 2023-02-17 | LABORATORY CORPORATION OF AMERICA HOLDINGS BURLINGTON, NC | 68968/643 | ECORSEXC, file of 2026-09-25 |
| 2024-07-03 | Assignment Assignment of assignor's interest | MACNEIL, ROBERT signed 2024-07-02 | LABORATORY CORPORATION OF AMERICA HOLDINGS BURLINGTON, NC | 67902/368 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.