Patents
US 12397060 B2: pHLIP®-mediated intracellular delivery of immuno-stimulatory compounds
- Granted
- 2025-08-26
- Filed
- 2020-01-28 application 17423849
- Type
- Utility · 22 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention features a composition comprising an immuno-stimulatory compound and a pHLIP® peptide, e.g., an immunostimulatory compound that comprises a cyclic purine dinucleotide, which binds to a stimulator of interferon genes (STING) such as a cGAMP cyclic compound inside a cell.
Source: PVGPATDIS, file of 2026-04-10 (ipg250826.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Rhode Island Board of Trustees 40 patents | US company or organization | Kingston, RI | PVGPATDIS, file of 2026-04-10 | |
| Yale University 871 patents | US company or organization | New Haven, CT | Yale University College or university EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yana K. Reshetnyak | Saunderstown, RI | 21 | PVGPATDIS, file of 2026-04-10 | |
| Oleg A. Andreev | Saunderstown, RI | 21 | PVGPATDIS, file of 2026-04-10 | |
| Donald M. Engelman | New Haven, CT | 18 | PVGPATDIS, file of 2026-04-10 | |
| Anna Moshnikova | Apponaug, RI | 4 | PVGPATDIS, file of 2026-04-10 | |
| John Deacon | Tolland, CT | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/64 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-12-06 | Government interest Confirmatory license | UNIVERSITY OF RHODE ISLAND signed 2021-07-26 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 65791/446 | ECORSEXC, file of 2026-09-25 |
| 2022-04-27 | Assignment Assignment of assignor's interest | MOSHNIKOVA, ANNA signed 2022-02-18 ANDREEV, OLEG A. signed 2022-02-25 RESHETNYAK, YANA K. signed 2022-03-25 | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES KINGSTON, RI | 59752/36 | ECORSEXC, file of 2026-09-25 |
| 2022-04-27 | Assignment Assignment of assignor's interest | ENGELMAN, DONALD M. signed 2022-03-18 DEACON, JOHN signed 2022-03-23 | YALE UNIVERSITY NEW HAVEN, CT | 59752/9 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.