Patents
US 12396995 B2: Substituted 4-aminoisoindoline-1,3-dione compounds and second active agents for combined use
- Granted
- 2025-08-26
- Filed
- 2023-01-23 application 18100426
- Type
- Utility · 34 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are methods of using (S)-2-(2,6-dioxopiperidin-3-yl)-4-((2-fluoro-4-((3-morpholinoazetidin-1-yl)methyl)benzyl)amino)isoindoline-1,3-dione, or an enantiomer, mixture of enantiomers, tautomer, isotopolog, or pharmaceutically acceptable salt thereof, in combination with a second active agent for treating, preventing or managing hematological malignancies. The second active agent is one or more of an HDAC inhibitor, a BCL2 inhibitor, a BTK inhibitor, an mTOR inhibitor, a PI3K inhibitor, a PKCĪ² inhibitor, a SYK inhibitor, a JAK2 inhibitor, an Aurora kinase inhibitor, an EZH2 inhibitor, a BET inhibitor, a hypomethylating agent, a DOT1L inhibitor, a HAT inhibitor, a WDR5 inhibitor, a DNMT1 inhibitor, an LSD-1 inhibitor, a G9A inhibitor, a PRMT5 inhibitor, a BRD inhibitor, a SUV420H1/H2 inhibitor, a CARM1 inhibitor, a PLK1 inhibitor, an NEK2 inhibitor, an MEK inhibitor, a PHF19 inhibitor, a PIM inhibitor, an IGF-1R inhibitor, an XPO1 inhibitor, a BIRC5 inhibitor, or a chemotherapy.
Source: PVGPATDIS, file of 2026-04-10 (ipg250826.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Celgene Corporation 413 patents | US company or organization | Summit, NJ | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Maria Soraya Carrancio Anton | San Diego, CA | 8 | PVGPATDIS, file of 2026-04-10 | |
| Tonia J. Buchholz | Moss Beach, CA | 7 | PVGPATDIS, file of 2026-04-10 | |
| Henry Chang | San Francisco, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Ellen Filvaroff | San Francisco, CA | 20 | PVGPATDIS, file of 2026-04-10 | |
| Shailaja Kasibhatla | San Diego, CA | 11 | PVGPATDIS, file of 2026-04-10 | |
| Antonia Lopez-Girona | San Diego, CA | 38 | PVGPATDIS, file of 2026-04-10 | |
| Adithi Mohan | San Mateo, CA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Rama Krishna Narla | San Diego, CA | 22 | PVGPATDIS, file of 2026-04-10 | |
| Michael Pourdehnad | San Francisco, CA | 18 | PVGPATDIS, file of 2026-04-10 | |
| William Pierceall | Madison, NJ | 5 | PVGPATDIS, file of 2026-04-10 | |
| Anjan Thakurta | Jalan Pedongkelan, NJ | 7 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/5377 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-08-11 | Correction Corrective assignment to correct the conveying party data on patent assignment cover sheet previously recorded at reel: 064264 frame: 0414. assignor(s) hereby confirms the assignment. | MOHAN, ADITHI signed 2021-01-15 BUCHHOLZ, TONIA J. signed 2021-01-19 FILVAROFF, ELLEN signed 2021-01-20 POURDEHNAD, MICHAEL signed 2021-04-07 PIERCEALL, WILLIAM EDWARD signed 2022-05-02 THAKURTA, ANJAN GUHA signed 2022-05-05 | CELGENE CORPORATION SUMMIT, NJ | 64572/78 | ECORSEXC, file of 2026-09-25 |
| 2023-08-10 | Assignment Assignment of assignor's interest | SIGNAL PHARMACEUTICALS, LLC signed 2022-01-26 | CELGENE CORPORATION SUMMIT, NJ | 64552/800 | ECORSEXC, file of 2026-09-25 |
| 2023-07-14 | Assignment Assignment of assignor's interest | CHANG, HENRY signed 2021-01-15 CARRANCIO ANTON, MARIA SORAYA signed 2021-01-16 NARLA, RAMA KRISHNA signed 2021-01-21 LOPEZ-GIRONA, ANTONIA signed 2021-01-25 KASIBHATLA, SHAILAJA signed 2021-03-11 | SIGNAL PHARMACEUTICALS, LLC SAN DIEGO, CA | 64264/871 | ECORSEXC, file of 2026-09-25 |
| 2023-07-14 | Assignment Assignment of assignor's interest | MOHAN, ADITHI signed 2021-01-15 BUCHHOLZ, TONIA J. signed 2021-01-19 FILVAROFF, ELLEN signed 2021-01-20 POURDEHNAD, MICHAEL signed 2021-04-07 | CELGENE CORPORATION SUMMIT, NJ | 64264/414 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.