Patents
US 12386895 B2: Systems and methods for genetic analysis
- Granted
- 2025-08-12
- Filed
- 2020-08-21 application 17000054
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention relates to using a graph database in genetic analyses to link mutation data to extrinsic data. Entities such as mutations, patients, samples, alleles, and clinical information are individually represented and stored as nodes and relationships between entities are also individually represented and stored. Each node and relationship can be stored using a fixed-size record and nodes can be flexibly invoked to represent any entity without disrupting the existing data. Systems and methods of the invention may be used for obtaining data representing a mutation in an individual and using a node in a graph database to store a description of the mutation. The node has stored within it a pointer to an adjacent node that provides information about a clinical significance of the variant. The graph database can be queried to provide a report of the clinical significance of the mutation.
Source: PVGPATDIS, file of 2026-04-10 (ipg250812.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Laboratory Corporation of America Holdings 128 patents | US company or organization | Burlington, NC | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Alexander Frieden | Somerville, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Caleb Kennedy | Arlington, MA | 17 | PVGPATDIS, file of 2026-04-10 | |
| Xavier S. Haurie | Belmont, MA | 3 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G06F | Electric digital data processing | G06F16/9024 | PVGPATDIS, file of 2026-04-10 |
| G16B | Bioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology | G16B20/20 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-08-30 | Assignment Assignment of assignor's interest | INVITAE CORPORATION signed 2024-08-05 | LABORATORY CORPORATION OF AMERICA HOLDINGS BURLINGTON, NC | 68822/25 | PASDL, file of 2026-10-15 |
| 2023-03-13 | Security interest Security interest Security interest | INVITAE CORPORATION signed 2023-03-07 | U.S. BANK TRUST COMPANY, NATIONAL ASSOCIATION, AS COLLATERAL AGENT ST. PAUL, MN | 63787/148 | PASDL, file of 2026-10-15 |
| 2023-03-06 | Release of security interest Release of security interest | PERCEPTIVE CREDIT HOLDINGS III, LP signed 2023-02-28 | INVITAE CORPORATION SAN FRANCISCO, CA GOOD START GENETICS, INC. SAN FRANCISCO, CA SINGULAR BIO, INC. SAN FRANCISCO, CA YOUSCRIPT, LLC SAN FRANCISCO, CA | 63282/538 | PASDL, file of 2026-10-15 |
| 2021-10-11 | Correction Corrective assignment to correct the the schedule a of the confirmatory assignment previously recorded at reel: 056756 frame: 0884. assignor(s) hereby confirms the assignment. | GOOD START GENETICS, INC. signed 2021-06-15 | INVITAE CORPORATION SAN FRANCISCO, CA | 57772/828 | PASDL, file of 2026-10-15 |
| 2021-09-01 | Assignment Assignment of assignor's interest | HAURIE, XAVIER S. signed 2014-11-05 FRIEDEN, ALEXANDER signed 2014-11-07 KENNEDY, CALEB J. signed 2014-12-22 | GOOD START GENETICS, INC. CAMBRIDGE, MA | 57352/767 | ECORSEXC, file of 2026-09-25 |
| 2021-07-02 | Assignment Assignment of assignor's interest | GOOD START GENETICS, INC. signed 2021-06-15 | INVITAE CORPORATION SAN FRANCISCO, CA | 56756/884 | PASDL, file of 2026-10-15 |
| 2020-10-02 | Security interest Security interest Patent security agreement | INVITAE CORPORATION signed 2020-10-02 GOOD START GENETICS, INC. signed 2020-10-02 SINGULAR BIO, INC. signed 2020-10-02 YOUSCRIPT, LLC signed 2020-10-02 | PERCEPTIVE CREDIT HOLDINGS III, LP NEW YORK, NY | 54234/872 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.