Patents
US 12385055 B2: Compositions and methods for production of salidroside, icariside D2, and precursors of salidroside and icariside D2
- Granted
- 2025-08-12
- Filed
- 2022-06-23 application 17847313
- Type
- Utility · 21 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Transgenic host cells, vectors useful for making transgenic host cells, and kits useful for making transgenic host cells are described. Also described are transgenic plants. In some embodiments, transgenic host cells express a 4-hydroxyphenylacetaldehyde synthase (4HPAAS). In some embodiments, transgenic host cells express a tyrosol:UDP-glucose 8-O-glucosyltransferase (T8GT). The transgenic host cells are useful for biosynthesis of one or more of salidroside, icariside D2, tyrosol, and 4-hydroxypenylacetaldehyde.
Source: PVGPATDIS, file of 2026-04-10 (ipg250812.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Whitehead Institute for Biomedical Research 176 patents | US company or organization | Cambridge, MA | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Michael Torrens-Spence | Cambridge, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Jing-Ke Weng | Belmont, MA | 8 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/8257 | PVGPATDIS, file of 2026-04-10 |
| C12P | Fermentation or enzyme-using processes to synthesise a desired chemical compound or composition or to separate optical isomers from a racemic mixture | C12P7/22 | PVGPATDIS, file of 2026-04-10 |
| C12Y | Enzymes | C12Y114/13068 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-07-05 | Assignment Assignment of assignor's interest | TORRENS-SPENCE, MICHAEL signed 2019-05-03 WENG, JING-KE signed 2019-05-03 | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH CAMBRIDGE, MA | 60396/408 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.