Patents
US 12371667 B2: Enhanced methods for inducing and maintaining naive human pluripotent stem cells
- Granted
- 2025-07-29
- Filed
- 2022-05-13 application 17744266
- Type
- Utility · 1 claim
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides methods and compositions for inducing, maintaining and/or passaging naïve pluripotent stem cell. In some embodiments, the methods are performed in the absence of MEK inhibition which has been shown to result in genomic instability of naïve pluripotent stem cells.
Source: PVGPATDIS, file of 2026-04-10 (ipg250729.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Washington University 798 patents | US company or organization | Chesterfield, MO | Washington University in St Louis College or university EXACT high confidence: through the nonprofit with the college's EIN (identical full name and state) WASHINGTON UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Whitehead Institute for Biomedical Research 176 patents | US company or organization | Cambridge, MA | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Thorold Theunissen | Chesterfield, MO | 2 | PVGPATDIS, file of 2026-04-10 | |
| Shafqat Khan | Chesterfield, MO | 1 | PVGPATDIS, file of 2026-04-10 | |
| Rudolf Jaenisch | Chesterfield, MO | 32 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0696 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-02-17 | Assignment Assignment of assignor's interest | KHAN, SHAFQAT signed 2022-05-23 THEUNISSEN, THOROLD signed 2022-05-30 | WASHINGTON UNIVERSITY ST. LOUIS, MO | 62728/311 | ECORSEXC, file of 2026-09-25 |
| 2023-02-17 | Assignment Assignment of assignor's interest | JAENISCH, RUDOLF signed 2021-08-10 | WHITEHEAD INSTITUTE FOR BIOMEDICAL RESEARCH CAMBRIDGE, MA | 62728/263 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.