Patents
US 12370261 B2: Chimeric peptides for antisense delivery
- Granted
- 2025-07-29
- Filed
- 2019-03-15 application 16981145
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided herein are oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates, the chimeric peptides and peptide-oligonucleotide-conjugates comprising at least two cell-penetrating peptides, wherein at least one of the cell-penetrating peptides is an amphipathic peptide and at least one of the cell-penetrating peptides is an oligoarginine peptide. The oligoarginine peptide comprises the sequence [(RYzR)x] (SEQ ID NOs: 15-18), wherein R is arginine, Y is independently selected from aminohexanoic acid (X) or β-alanine (B). Also provided herein are methods of treating a muscle disease, a viral infection, or a bacterial infection in a subject in need thereof, comprising administering to the subject oligonucleotides, chimeric peptides, and peptide-oligonucleotide-conjugates comprising at least two cell-penetrating peptides, wherein at least one of the cell-penetrating peptides is an amphipathic peptide and at least one of the cell-penetrating peptides is an oligoarginine peptide described herein.
Source: PVGPATDIS, file of 2026-04-10 (ipg250729.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| SAREPTA THERAPEUTICS, INC. 126 patents | US company or organization | Cambridge, MA | Sarepta Therapeutics, Inc. Form D issuer EXACT high confidence: identical full name and state SAREPTA THERAPEUTICS, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY 5,106 patents | US company or organization | Cambridge, MA | Massachusetts Institute of Technology College or university EXACT high confidence: identical full name and state MASSACHUSETTS INSTITUTE OF TECHNOLOGY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Bradley L. Pentelute | Cambridge, MA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Colin M. Fadzen | Cambridge, MA | 4 | PVGPATDIS, file of 2026-04-10 | |
| Rebecca L. Holden | Cambridge, MA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Justin Wolfe | Cambridge, MA | 12 | PVGPATDIS, file of 2026-04-10 | |
| Zi-Ning Choo | Cambridge, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Monica Yao | Cambridge, MA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Gunnar J. Hanson | Cambridge, MA | 58 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/645 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P21/00 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/113 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-04-25 | Correction Corrective assignment to correct the assignee name previously recorded at reel: 70784 frame: 690. assignor(s) hereby confirms the assignment. | WOLFE, JUSTIN M. signed 2023-02-06 CHOO, ZI-NING signed 2023-02-08 PENTELUTE, BRADLEY L. signed 2024-01-03 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 71050/880 | ECORSEXC, file of 2026-09-25 |
| 2025-04-09 | Assignment Assignment of assignor's interest | HANSON, GUNNAR J. signed 2020-10-15 YAO, MONICA signed 2020-10-20 | SAREPTA THERAPEUTICS, INC. CAMBRIDGE, MA | 70786/175 | ECORSEXC, file of 2026-09-25 |
| 2025-04-09 | Assignment Assignment of assignor's interest | WOLFE, JUSTIN M. signed 2023-02-06 CHOO, ZI-NING signed 2023-02-08 PENTELUTE, BRADLEY L. signed 2024-01-03 | MASSACHUSETTS INSTITUTES OF TECHNOLOGY CAMBRIDGE, MA | 70784/690 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.