Patents
US 12285462 B2: pH-triggered membrane peptide-mediated epitope tethering at cell surfaces
- Granted
- 2025-04-29
- Filed
- 2023-05-30 application 18325884
- Type
- Utility · 18 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention features methods and compositions for eliciting an anti-tumor response in a subject comprising administering to the subject a pHLIP● construct comprising an antibody recruiting molecule linked to one or more pHLIP● peptides by a non-cleavable linker compound. The construct increases the amount of the antibody recruiting molecule on the surface of a diseased cell.
Source: PVGPATDIS, file of 2026-04-10 (ipg250429.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| University of Rhode Island Board of Trustees 40 patents | US company or organization | Kingston, RI | PVGPATDIS, file of 2026-04-10 | |
| Yale University 871 patents | US company or organization | New Haven, CT | Yale University College or university EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yana K. Reshetnyak | Saunderstown, RI | 21 | PVGPATDIS, file of 2026-04-10 | |
| Oleg A. Andreev | Saunderstown, RI | 21 | PVGPATDIS, file of 2026-04-10 | |
| Anna Moshnikova | Apponaug, RI | 4 | PVGPATDIS, file of 2026-04-10 | |
| Donald M. Engelman | New Haven, CT | 18 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/16 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K2319/33 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2025-01-24 | Assignment Assignment of assignor's interest | ENGELMAN, DONALD M. signed 2020-07-10 | YALE UNIVERSITY NEW HAVEN, CT | 70007/353 | ECORSEXC, file of 2026-09-25 |
| 2025-01-24 | Assignment Assignment of assignor's interest | ANDREEV, OLEG A. signed 2020-07-31 MOSHNIKOVA, ANNA signed 2020-07-31 RESHETNYAK, YANA K. signed 2020-07-31 | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES KINGSTON, RI | 70007/338 | ECORSEXC, file of 2026-09-25 |
| 2024-01-24 | Government interest Confirmatory license | UNIVERSITY OF RHODE ISLAND signed 2023-10-16 | NATIONAL INSTITUTES OF HEALTH (NIH), U.S. DEPT. OF HEALTH AND HUMAN SERVICES (DHHS), U.S. GOVERNMENT BETHESDA, MD | 66369/530 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.