Patents
US 12282022 B2: Nanoplasmonic quantification of tumor-derived extracellular vesicles in plasma microsamples for detection and treatment monitoring
- Granted
- 2025-04-22
- Filed
- 2017-12-28 application 16469082
- Type
- Utility · 8 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A rapid, ultrasensitive and inexpensive nanoplasmon-enhanced scattering (nPES) assay that directly quantifies tumor-derived EVs from as little as 1 μ{umlaut over ({acute over (ι)})}, of plasma is described herein. This assay uses binding of gold nanospheres and nanorods with EV- and tumor-derived EV-specificities to produce a local plasmon effect that enhances tumor-derived EV detection sensitivity and specificity. This nPES approach is also a non-invasive method for assessing pancreatic cancer stage and treatment response that can be easily refined for clinical use, and is readily adapted for diagnosis and monitoring of other conditions with disease-specific EV proteins.
Source: PVGPATDIS, file of 2026-04-10 (ipg250422.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| The Methodist Hospital 51 patents | US company or organization | Houston, TX | THE METHODIST HOSPITAL State business registration EXACT high confidence: identical full name and state THE METHODIST HOSPITAL Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Ye Hu | Scottsdale, AZ | 4 | PVGPATDIS, file of 2026-04-10 | |
| Jia Fan | Pearland, TX | 3 | PVGPATDIS, file of 2026-04-10 | |
| Kai Liang | Beijing, CN | 1 | PVGPATDIS, file of 2026-04-10 | |
| Fei Liu | Cupertino, CA | 287 | PVGPATDIS, file of 2026-04-10 | |
| Dali Sun | Tempe, AZ | 6 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/57525 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2021-03-11 | Assignment Assignment of assignor's interest | LIU, FEI signed 2018-11-01 LIANG, KAI signed 2018-11-16 SUN, DALI signed 2018-11-26 FAN, JIA signed 2018-12-07 HU, YE signed 2018-12-07 | THE METHODIST HOSPITAL DBA HOUSTON METHODIST HOUSTON, TX | 55565/55 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.