Patents
US 12254959 B2: Identification, characterization, and quantitation of CRISPR-introduced double-stranded DNA break repairs
- Granted
- 2025-03-18
- Filed
- 2020-07-02 application 16919577
- Type
- Utility · 9 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein is a system and process for identifying and characterizing double-stranded DNA break repair sites that are based on biological information and have improved accuracy. Also described is a sequence alignment process that uses biological data to inform the alignment matrix for position specific alignment scoring, resulting in the identification of noncanonical target sites.
Source: PVGPATDIS, file of 2026-04-10 (ipg250318.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| INTEGRATED DNA TECHNOLOGIES, INC. 103 patents | US company or organization | Coralville, IA | INTEGRATED DNA TECHNOLOGIES, INC. State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Heng Li | Wellesley, MA | 13 | PVGPATDIS, file of 2026-04-10 | |
| Gavin Kurgan | Iowa City, IA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Matthew McNeill | Iowa City, IA | 4 | PVGPATDIS, file of 2026-04-10 | |
| Yu Wang | North Grafton, MA | 24 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| G16B | Bioinformatics, i.e. information and communication technology [ict] specially adapted for genetic or protein-related data processing in computational molecular biology | G16B20/30 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2020-08-18 | Assignment Assignment of assignor's interest | KURGAN, GAVIN signed 2020-07-17 WANG, YU signed 2020-07-17 MCNEILL, MATTHEW signed 2020-07-19 LI, HENG signed 2020-08-17 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 53531/805 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.