Patents
US 12246097 B2: Nanoparticle vaccine adjuvant and methods of use thereof
- Granted
- 2025-03-11
- Filed
- 2023-01-06 application 18151182
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Non-liposome, non-micelle particles formed of a lipid, an additional adjuvant such as a TLR4 agonist, a sterol, and a saponin are provided. The particles are porous, cage-like nanoparticles, also referred to as nanocages, and are typically between about 30 nm and about 60 nm. In some embodiments, the nanocages include or are administered in combination with an antigen. The particles can increase immune responses and are particularly useful as adjuvants in vaccine applications and related methods of treatment. Preferred lipids, additional adjuvants including TLR4 agonists, sterols, and saponins, methods of making the nanocages, and method of using them are also provided.
Source: PVGPATDIS, file of 2026-04-10 (ipg250311.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| MASSACHUSETTS INSTITUTE OF TECHNOLOGY 5,106 patents | US company or organization | Cambridge, MA | Massachusetts Institute of Technology College or university EXACT high confidence: identical full name and state MASSACHUSETTS INSTITUTE OF TECHNOLOGY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| LA JOLLA INSTITUTE FOR IMMUNOLOGY 2 patents | US company or organization | Village of La Jolla, CA | LA JOLLA INSTITUTE FOR IMMUNOLOGY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Darrell J. Irvine | Arlington, MA | 59 | PVGPATDIS, file of 2026-04-10 | |
| Murillo Silva | Lancaster, MA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Shane Crotty | San Diego, CA | 6 | Person page FUZZY high confidence | PVGPATDIS, file of 2026-04-10 |
| Yu Kato | San Diego, CA | 7 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K9/127 | PVGPATDIS, file of 2026-04-10 |
| B82Y | Specific uses or applications of nanostructures; measurement or analysis of nanostructures; manufacture or treatment of nanostructures | B82Y5/00 | PVGPATDIS, file of 2026-04-10 |
| Y02A | Technologies for adaptation to climate change | Y02A50/30 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-10-23 | Assignment Assignment of assignor's interest | HOWARD HUGHES MEDICAL INSTITUTE signed 2019-09-19 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 68983/840 | ECORSEXC, file of 2026-09-25 |
| 2024-10-23 | Assignment Assignment of assignor's interest | IRVINE, DARRELL signed 2018-08-21 | HOWARD HUGHES MEDICAL INSTITUTE CHEVY CHASE, MD | 68983/822 | ECORSEXC, file of 2026-09-25 |
| 2024-10-23 | Assignment Assignment of assignor's interest | SILVA, MURILLO signed 2019-09-19 | MASSACHUSETTS INSTITUTE OF TECHNOLOGY CAMBRIDGE, MA | 68982/793 | ECORSEXC, file of 2026-09-25 |
| 2024-10-23 | Assignment Assignment of assignor's interest | CROTTY, SHANE signed 2020-08-08 KATO, YU signed 2020-08-08 | LA JOLLA INSTITUTE FOR IMMUNOLOGY LA JOLLA, CA | 68982/594 | ECORSEXC, file of 2026-09-25 |
| 2024-10-23 | Name change Change of name | LA JOLLA INSTITUTE FOR IMMUNOLOGY. signed 2019-01-28 | LA JOLLA INSTITUTE FOR IMMUNOLOGY LA JOLLA, CA | 68982/367 | ECORSEXC, file of 2026-09-25 |
| 2024-10-23 | Name change Change of name | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY signed 2018-10-22 | LA JOLLA INSTITUTE FOR IMMUNOLOGY. LA JOLLA, CA | 68982/362 | ECORSEXC, file of 2026-09-25 |
| 2024-10-23 | Assignment Assignment of assignor's interest | CROTTY, SHANE signed 2018-11-30 KATO, YU signed 2018-11-30 | LA JOLLA INSTITUTE FOR ALLERGY AND IMMUNOLOGY LA JOLLA, CA | 68982/334 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.