Patents
US 12246062 B2: Recombinant human acid alpha-glucosidase
- Granted
- 2025-03-11
- Filed
- 2018-05-15 application 16613919
- Type
- Utility · 19 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Provided are a recombinant acid α-glucosidase and pharmaceutical composition comprising a recombinant acid α-glucosidase, wherein the recombinant acid α-glucosidase is expressed in Chinese hamster ovary (CHO) cells and comprises an increased content of N-glycan units bearing one or two mannose-6-phosphate residues when compared to a content of N-glycan units bearing one or two mannose-6-phosphate residues of alglucosidase alfa. Also provided herein are methods of producing, purifying, and formulating the recombinant acid α-glucosidase or pharmaceutical composition for administration to a subject and methods of treating a disease or disorder such as Pompe disease using the recombinant acid α-glucosidase or pharmaceutical composition.
Source: PVGPATDIS, file of 2026-04-10 (ipg250311.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Amicus Therapeutics, Inc. 158 patents | US company or organization | Philadelphia, PA | AMICUS THERAPEUTICS, INC. Form D issuer EXACT high confidence: identical full name and state AMICUS THERAPEUTICS, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Hung V. Do | New Hope, PA | 33 | PVGPATDIS, file of 2026-04-10 | |
| Russell Gotschall | Doylestown, PA | 17 | PVGPATDIS, file of 2026-04-10 | |
| Richie Khanna | Raritan, NJ | 14 | PVGPATDIS, file of 2026-04-10 | |
| Yi Lun | Plainsboro, NJ | 1 | PVGPATDIS, file of 2026-04-10 | |
| Hing Char | East Brunswick Township, NJ | 6 | PVGPATDIS, file of 2026-04-10 | |
| Sergey Tesler | Monroe, NJ | 8 | PVGPATDIS, file of 2026-04-10 | |
| Wendy Sunderland | Doylestown, PA | 4 | PVGPATDIS, file of 2026-04-10 | |
| Enrique Diloné | Jalan Pedongkelan, NJ | 6 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/47 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P21/00 | PVGPATDIS, file of 2026-04-10 |
| C12Y | Enzymes | C12Y302/0102 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-04-27 | Release of security interest Release of security interest | WILMINGTON TRUST, NATIONAL ASSOCIATION signed 2026-04-27 | AMICUS THERAPEUTICS, INC. PHILADELPHIA, PA | 75494/30 | PASDL, file of 2026-08-13 |
| 2026-04-27 | Security interest Security interest Security interest | BIOMARIN PHARMACEUTICAL INC. signed 2026-04-27 AMICUS THERAPEUTICS, INC. signed 2026-04-27 | CITIBANK, N.A., AS COLLATERAL AGENT NEW YORK, NY | 75493/968 | PASDL, file of 2026-10-15 |
| 2024-12-05 | Assignment Assignment of assignor's interest | DO, HUNG V. signed 2024-11-17 | AMICUS THERAPEUTICS, INC. PHILADELPHIA, PA | 69499/348 | ECORSEXC, file of 2026-09-25 |
| 2024-11-12 | Assignment Assignment of assignor's interest | CHAR, HING signed 2024-09-11 GOTSCHALL, RUSSELL signed 2024-09-11 TESLER, SERGEY signed 2024-09-12 SUNDERLAND, WENDY signed 2024-09-18 KHANNA, RICHIE signed 2024-09-23 LUN, YI signed 2024-10-06 DILONE, ENRIQUE signed 2024-11-11 | AMICUS THERAPEUTICS, INC. PHILADELPHIA, PA | 69228/921 | ECORSEXC, file of 2026-09-25 |
| 2023-10-06 | Security interest Security interest Security interest | AMICUS THERAPEUTICS, INC. signed 2023-10-05 | WILMINGTON TRUST, NATIONAL ASSOCIATION MINNEAPOLIS, MN | 65177/196 | PASDL, file of 2026-10-15 |
| 2023-10-06 | Release of security interest Release of security interest | HAYFIN SERVICES LLP signed 2023-10-05 | AMICUS THERAPEUTICS, INC. PRINCETON, NJ | 65164/945 | PASDL, file of 2026-10-15 |
| 2020-07-30 | Security interest Security interest Security interest | AMICUS THERAPEUTICS, INC. signed 2020-07-30 | HAYFIN SERVICES LLP, AS AGENT LONDON | 53365/342 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.