Patents
US 12134797 B2: Hybridization capture methods and compositions
- Granted
- 2024-11-05
- Filed
- 2021-03-25 application 17212247
- Type
- Utility · 21 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein are methods and compositions for improved hybridization capture for enriching for target nucleic acid sequences from a population of nucleic acids. In one aspect, the methods and compositions are useful for Next Generation Sequencing (NGS) applications. The methods and compositions include combining in solution capture probes and target nucleic acid and permitting hybridization of the target nucleic acid to the capture probes under conditions to promote efficient hybridization. Following hybridization, the probe/target complex is immobilized to a capture material while simultaneously incubating at an optimum hybridization temperature. The incubation denatures unwanted nucleic acids from the capture probes further enriching for target nucleic acid.
Source: PVGPATDIS, file of 2026-04-10 (ipg241105.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| INTEGRATED DNA TECHNOLOGIES, INC. 103 patents | US company or organization | Coralville, IA | INTEGRATED DNA TECHNOLOGIES, INC. State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Alexandra Hui Wang | Mountain View, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Katharine Dilger | Foster City, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Rachael Cunningham | Los Altos, CA | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6832 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-10-20 | Assignment Assignment of assignor's interest | WANG, ALEXANDRA HUI signed 2023-08-29 DILGER, KATHARINE signed 2023-10-07 CUNNINGHAM, RACHAEL signed 2023-10-18 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 65294/944 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.