Patents
US 12123033 B2: Modified double-stranded donor templates
- Granted
- 2024-10-22
- Filed
- 2020-10-23 application 17079097
- Type
- Utility · 7 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein are compositions and methods for improving homology directed repair (HDR) efficiency and reducing homology-independent integration following introduction of double strand breaks with engineered nucleases. Additionally, modifications to double stranded DNA donors to improve the donor potency and efficiency of homology directed repair following introduction of double stranded breaks with programmable nucleases.
Source: PVGPATDIS, file of 2026-04-10 (ipg241022.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| INTEGRATED DNA TECHNOLOGIES, INC. 103 patents | US company or organization | Coralville, IA | INTEGRATED DNA TECHNOLOGIES, INC. State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jessica Woodley | North Liberty, IA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Bernice Thommandru | Iowa City, IA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Joseph Dobosy | Coralville, IA | 12 | PVGPATDIS, file of 2026-04-10 | |
| Mark Aaron Behlke | Coralville, IA | 74 | PVGPATDIS, file of 2026-04-10 | |
| Adam Clore | Iowa City, IA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Garrett Richard Rettig | Coralville, IA | 15 | PVGPATDIS, file of 2026-04-10 | |
| Beimeng Sun | North Liberty, IA | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/22 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2020-12-18 | Assignment Assignment of assignor's interest | WOODLEY, JESSICA signed 2020-10-30 THOMMANDRU, BERNICE signed 2020-10-30 DOBOSY, JOSEPH signed 2020-10-30 BEHLKE, MARK signed 2020-11-02 CLORE, ADAM signed 2020-10-29 RETTIG, GARRETT signed 2020-11-08 SUN, BEIMENG signed 2020-12-14 | INTEGRATED DNA TECHNOLOGIES, INC. CORALVILLE, IA | 54691/712 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.