Patents
US 12065660 B2: Transgenic silkworms expressing hagfish thread keratin
- Granted
- 2024-08-20
- Filed
- 2020-08-17 application 16995372
- Type
- Utility · 10 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Transgenic silkworms stably expressing hagfish thread keratin genes or composite silkworm/hagfish thread keratin genes are disclosed. The exogenous hagfish thread keratin genes are stably integrated into a defined site of the fibroin heavy chain intron or a fibroin light chain intron of silkworms. Synthetic hagfish thread keratin proteins and composite hagfish thread keratin-silkworm genes and proteins are provided. The expression of exogenous hagfish thread keratin genes is driven by the endogenous fibroin heavy chain promoter, improving the genetic stability of transgenic silkworms. The composite silkworm/hagfish thread keratin fibers exhibit exceptional mechanical performance, compared to normal silkworm silk fibers and other transgenic silkworm fibers.
Source: PVGPATDIS, file of 2026-04-10 (ipg240820.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Utah State University 160 patents | US company or organization | North Logan, UT | Utah State University College or university EXACT high confidence: identical full name and state UTAH STATE UNIVERSITY Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Randolph V. Lewis | Nibley, UT | 9 | PVGPATDIS, file of 2026-04-10 | |
| Justin A. Jones | Nibley, UT | 10 | PVGPATDIS, file of 2026-04-10 | |
| Xiaoli Zhang | Nibley, UT | 20 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/43586 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N15/8509 | PVGPATDIS, file of 2026-04-10 |
| A01K | Animal husbandry; aviculture; apiculture; pisciculture; fishing; rearing or breeding animals, not otherwise provided for; new breeds of animals | A01K67/68 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-07-03 | Assignment Assignment of assignor's interest | ZHANG, XIAOLI signed 2024-05-16 | UTAH STATE UNIVERSITY LOGAN, UT | 67907/109 | ECORSEXC, file of 2026-09-25 |
| 2020-09-15 | Assignment Assignment of assignor's interest | JONES, JUSTIN signed 2020-08-19 LEWIS, RANDOLPH V. signed 2020-08-19 | UTAH STATE UNIVERSITY NORTH LOGAN, UT | 53779/112 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.