Patents
US 12029793 B2: pH low insertion peptide targeted delivery of potent cytotoxic compounds
- Granted
- 2024-07-09
- Filed
- 2020-01-28 application 16774966
- Type
- Utility · 69 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention features a composition comprising a potent cytotoxic compound and a pH low insertion peptide, where, e.g., the cytotoxic compound cannot be used alone due to a lack of targeting. The pH low insertion peptide targets cytotoxic compounds to acidic diseased tissue, translocates cytotoxic compounds across plasma membranes into the cytosols of cells in acidic diseased tissues and induces cell death predominantly in the targeted acidic diseased tissue.
Source: PVGPATDIS, file of 2026-04-10 (ipg240709.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Yale University 871 patents | US company or organization | New Haven, CT | Yale University College or university EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| University of Rhode Island Board of Trustees 40 patents | US company or organization | Kingston, RI | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Yana K. Reshetnyak | Saunderstown, RI | 21 | PVGPATDIS, file of 2026-04-10 | |
| Oleg A. Andreev | Saunderstown, RI | 21 | PVGPATDIS, file of 2026-04-10 | |
| Anna Moshnikova | Apponaug, RI | 4 | PVGPATDIS, file of 2026-04-10 | |
| Donald M. Engelman | New Haven, CT | 18 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/537 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2020-06-02 | Assignment Assignment of assignor's interest | RESHETNYAK, YANA K. signed 2020-05-22 ANDREEV, OLEG A. signed 2020-05-22 MOSHNIKOVA, ANNA signed 2020-05-22 | UNIVERSITY OF RHODE ISLAND BOARD OF TRUSTEES KINGSTON, RI | 52814/130 | PASDL, file of 2026-10-15 |
| 2020-06-02 | Assignment Assignment of assignor's interest | ENGELMAN, DONALD M. signed 2020-05-21 | YALE UNIVERSITY NEW HAVEN, CT | 52814/51 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.