Patents
US 12006373 B1: Identification and evaluation of novel peptide ligands specific to human CD3 epsilon
- Granted
- 2024-06-11
- Filed
- 2021-06-16 application 17349825
- Type
- Utility · 5 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure is directed to anti-CD3ε peptides, compounds, and methods of using same. A biopanning technique was used to identify several phage clones displaying unique anti-CD3ε peptide sequences. The anti-CD3ε peptide sequences bind to human CD3ε on T cells, allowing the identification, labeling, and delivery of cargo to these T cells. Applications for the disclosed peptides include the labeling of T cells with magnetic particles for MRI detection and targeting of T cells with cargo-laden anti-CD3ε peptides for immunotherapy. Further still, incubation of T cells with anti-CD3ε peptides may result in the activation and increase production of T cells, which may in turn be harvested for applications such as CAR-T therapy.
Source: PVGPATDIS, file of 2026-04-10 (ipg240611.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Board of Trustees of the Univeristy of Alabama, for and on behalf of the University of Alabama in Huntsville 88 patents | US company or organization | Huntsville, AL | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Kyung-Ho Roh | Madison, AL | 5 | PVGPATDIS, file of 2026-04-10 | |
| Armin Ahmadi | Huntsville, AL | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/62 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K5/1008 | PVGPATDIS, file of 2026-04-10 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N2333/70596 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-11-27 | Assignment Assignment of assignor's interest | AHMADI, ARMIN signed 2023-10-18 ROH, KYUNG HO signed 2023-10-24 | BOARD OF TRUSTEES OF THE UNIVERSITY OF ALABAMA, FOR AND ON BEHALF OF THE UNIVERSITY OF ALABAMA IN HUNTSVILLE HUNTSVILLE, AL | 65665/188 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.