Patents
US 11866493 B2: Single-chain variable fragment of Met monoclonal antibody and methods of use in CAR T cell therapy
- Granted
- 2024-01-09
- Filed
- 2020-11-02 application 17086839
- Type
- Utility · 13 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A single-chain variable fragment (ScFv) derived from anti-c-Met monoclonal antibody MetMAb that specifically binds to c-Met receptor is provided. Also provided are chimeric antigen receptor (CAR) vectors including the ScFv, human T cells transduced with the disclosed CAR vectors, pharmaceutical compositions including the CAR T cells, ScFv fusion proteins, and methods of treating a c-Met-positive cancer or a cancer characterized by overexpression of c-Met in a subject in need thereof by administering an effective amount of the disclosed CAR T cells.
Source: PVGPATDIS, file of 2026-04-10 (ipg240109.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| East Tennessee State University Research Foundation 6 patents | US company or organization | Johnson City, TN | EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATION Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Qian Xie | Johnson City, TN | 16 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K16/28 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K40/11 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-09-11 | Government interest Confirmatory license | EAST TENNESSEE STATE UNIVERSITY signed 2024-06-10 | UNITED STATES GOVERNMENT FORT DETRICK, MD | 68926/960 | ECORSEXC, file of 2026-09-25 |
| 2020-11-02 | Assignment Assignment of assignor's interest | XIE, QIAN signed 2019-12-11 | EAST TENNESSEE STATE UNIVERSITY RESEARCH FOUNDATION JOHNSON CITY, TN | 54278/476 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.