Patents
US 11752174 B2: Placental tissue grafts and improved methods of preparing and using the same
- Granted
- 2023-09-12
- Filed
- 2020-12-14 application 17120626
- Type
- Utility · 18 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein are tissue grafts derived from the placenta. The grafts are composed of at least one layer of amnion tissue where the epithelium layer has been substantially removed in order to expose the basement layer to host cells. By removing the epithelium layer, cells from the host can more readily interact with the cell-adhesion bio-active factors located onto top and within of the basement membrane. Also described herein are methods for making and using the tissue grafts. The laminin structure of amnion tissue is nearly identical to that of native human tissue such as, for example, oral mucosa tissue. This includes high level of laminin-5, a cell adhesion bio-active factor show to bind gingival epithelia-cells, found throughout upper portions of the basement membrane.
Source: PVGPATDIS, file of 2026-04-10 (ipg230912.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| MiMedx Group, Inc. 115 patents | US company or organization | Marietta, GA | MIMEDX GROUP, INC. Form D issuer EXACT high confidence: identical full name and state MIMEDX GROUP, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| John Daniel | Woodstock, GA | 63 | PVGPATDIS, file of 2026-04-10 | |
| Randall Spencer | Acworth, GA | 40 | PVGPATDIS, file of 2026-04-10 | |
| John Russo | Sarasota, FL | 17 | PVGPATDIS, file of 2026-04-10 | |
| Robert Tofe | Denver, CO | 30 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K35/28 | PVGPATDIS, file of 2026-04-10 |
| A61L | Methods or apparatus for sterilising materials or objects in general; disinfection, sterilisation or deodorisation of air; chemical aspects of bandages, dressings, absorbent pads or surgical articles; materials for bandages, dressings, absorbent pads or surgical articles | A61L27/3604 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P41/00 | PVGPATDIS, file of 2026-04-10 |
| A61F | Filters implantable into blood vessels; prostheses; devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents; orthopaedic, nursing or contraceptive devices; fomentation; treatment or protection of eyes or ears; bandages, dressings or absorbent pads; first-aid kits | A61F2210/00 | PVGPATDIS, file of 2026-04-10 |
| Y10T | Technical subjects covered by former us classification | Y10T156/10 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-01-25 | Security interest Security interest Security interest | MIMEDX GROUP, INC. signed 2024-01-19 | CITIZENS BANK, N.A. PROVIDENCE, RI | 66371/136 | PASDL, file of 2026-10-15 |
| 2021-03-12 | Assignment Assignment of assignor's interest | SNOASIS MEDICAL, INC. signed 2013-10-04 | SURGICAL BIOLOGICS, LLC MARIETTA, GA | 55577/558 | PASDL, file of 2026-10-15 |
| 2021-03-12 | Assignment Assignment of assignor's interest | TOFE, ROBERT signed 2013-10-08 | SNOASIS MEDICAL, INC. DENVER, CO | 55577/551 | PASDL, file of 2026-10-15 |
| 2021-03-12 | Assignment Assignment of assignor's interest | SURGICAL BIOLOGICS, LLC signed 2012-10-22 | MIMEDX GROUP, INC. MARIETTA, GA | 55577/545 | PASDL, file of 2026-10-15 |
| 2021-03-12 | Assignment Assignment of assignor's interest | DANIEL, JOHN signed 2012-09-27 SPENCER, RANDALL signed 2012-09-27 RUSSO, JOHN signed 2012-09-27 | SURGICAL BIOLOGICS, LLC KENNESAW, GA | 55577/505 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.