Patents
US 11440948 B2: Modified non-natural NKG2D ligands that selectively deliver attached heterologous molecules to non-natural NKG2D receptors on car-cells
- Granted
- 2022-09-13
- Filed
- 2020-01-28 application 16774567
- Type
- Utility · 7 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
This application relates generally to the production of modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides having specific target-binding properties, for example, antibodies or variable fragments of antibodies, that are selectively delivered to Chimeric Antigen Receptors (CARs) comprised of modified, non-natural NKG2D receptors on engineered mammalian cells. The targeting of surface-expressed molecules includes those of virus-infected cells that can then be attacked and ablated by engineered cells of the immunity system expressing CARs cognate to the modified, non-natural α1-α2 domains of NKG2D ligands with attached polypeptides.
Source: PVGPATDIS, file of 2026-04-10 (ipg220913.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| XYPHOS BIOSCIENCES INC. 6 patents | US company or organization | South San Francisco, CA | PVGPATDIS, file of 2026-04-10 | |
| The J. David Gladstone Institutes 72 patents | US company or organization | San Francisco, CA | J. DAVID GLADSTONE INSTITUTES State business registration FUZZY medium confidence: same name (legal endings aside) and state J DAVID GLADSTONE INSTITUTES Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Kaman Kim | South San Francisco, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Nigel Killeen | South San Francisco, CA | 7 | PVGPATDIS, file of 2026-04-10 | |
| Eytan Herzig | South San Francisco, CA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Warner C. Greene | South San Francisco, CA | 9 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/7056 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/395 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P31/18 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-06-29 | Assignment Assignment of assignor's interest | GREENE, WARNER signed 2021-11-24 | THE J. DAVID GLADSTONE INSTITUTES SAN FRANCISCO, CA | 60355/845 | ECORSEXC, file of 2026-09-25 |
| 2022-06-29 | Assignment Assignment of assignor's interest | HERZIG, EYTAN signed 2021-12-01 | THE J. DAVID GLADSTONE INSTITUTES SAN FRANCISCO, CA | 60355/651 | ECORSEXC, file of 2026-09-25 |
| 2022-06-29 | Assignment Assignment of assignor's interest | KIM, KAMAN signed 2022-06-02 KILLEEN, NIGEL signed 2022-06-13 | XYPHOS BIOSCIENCES INC. SOUTH SAN FRANCISCO, CA | 60355/126 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.