Patents
US 11384084 B2: First-in-class of SHMT2 and MTHFD2 inhibitors as antitumor agents
- Granted
- 2022-07-12
- Filed
- 2020-08-26 application 17002912
- Type
- Utility · 11 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
A compound of the Formula I and optionally a pharmaceutically acceptable salt thereof is provided: Formula I, wherein, R is one selected from the group consisting of H and CH3; n is an integer 4 when X is —CH2— and Ar is 1,4-phenyl, or n is an integer ranging from 1 to 4 when X is —CH2— and Ar is either 2′-fluoro-1,4-phenyl or 2,5-thienyl, or n is an integer ranging from 1 to 4 when X is one selected from the group consisting of O, S, —NH—, —NHCHO—, —NHCOCH3—, and —NHCOCF3— and Ar is one selected from the group consisting of (a) 1,4-phenyl, (b) 2′-fluoro-1,4-phenyl, and (c) 2,5-thienyl, or n is an integer 3 when X is —CH2—, R is CH3 and Ar is 1,4-phenyl.
Source: PVGPATDIS, file of 2026-04-10 (ipg220712.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Duquesne University of the Holy Spirit 70 patents | US company or organization | Pittsburgh, PA | Duquesne University College or university EXACT high confidence: through the nonprofit with the college's EIN (identical full name and state) DUQUESNE UNIVERSITY OF THE HOLY SPIRIT Federal lobbying client EXACT high confidence: identical full name and state DUQUESNE UNIVERSITY OF THE HOLY SPIRIT Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| Wayne State University 333 patents | US company or organization | Detroit, MI | Wayne State University College or university EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Aleem Gangjee | Allison Park, PA | 65 | Person page FUZZY high confidence | PVGPATDIS, file of 2026-04-10 |
| Larry H. Matherly | Novi, MI | 14 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D487/04 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K31/519 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-06-08 | Assignment Assignment of assignor's interest | MATHERLY, LARRY signed 2018-11-27 GANGJEE, ALEEM signed 2018-12-13 | WAYNE STATE UNIVERSITY DETROIT, MI | 60139/234 | ECORSEXC, file of 2026-09-25 |
| 2020-08-26 | Assignment Assignment of assignor's interest | MATHERLY, LARRY H. signed 2018-11-27 GANGJEE, ALEEM signed 2018-12-13 | DUQUESNE UNIVERSITY OF THE HOLY SPIRIT PITTSBURGH, PA | 53599/234 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.