Patents
US 11338063 B2: Placental tissue grafts modified with a cross-linking agent and methods of making and using the same
- Granted
- 2022-05-24
- Filed
- 2013-03-15 application 13815747
- Type
- Utility · 27 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Described herein are tissue grafts derived from the placenta that possess good adhesion to biological tissues and are useful in wound healing applications. In one aspect, the tissue graft includes (1) two or more layers of amnion, wherein at least one layer of amnion is cross-linked, (2) two or more layers of chorion, wherein at least one layer of chorion is cross-linked, or (3) one or more layers of amnion and chorion, wherein at least one layer of amnion and/or chorion is cross-linked. In another aspect, the grafts are composed of amnion and chorion cross-linked with one another. In a further aspect, the grafts have one or more layers sandwiched between the amnion and chorion membranes. The amnion and/or the chorion are treated with a cross-linking agent prior to the formation of the graft. The presence of the cross-linking agent present on the graft also enhances adhesion to the biological tissue of interest. Also described herein are methods for making and using the tissue grafts.
Source: PVGPATDIS, file of 2026-04-10 (ipg220524.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| MiMedx Group, Inc. 115 patents | US company or organization | Marietta, GA | MIMEDX GROUP, INC. Form D issuer EXACT high confidence: identical full name and state MIMEDX GROUP, INC. SEC filer EXACT medium confidence: identical full name, one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| John Daniel | Kennesaw, GA | 63 | PVGPATDIS, file of 2026-04-10 | |
| Randall Spencer | Kennesaw, GA | 40 | PVGPATDIS, file of 2026-04-10 | |
| Brenda S. Morse | Kennesaw, GA | 14 | Person page FUZZY medium confidence | PVGPATDIS, file of 2026-04-10 |
| Thomas J. Koob | Kennesaw, GA | 71 | PVGPATDIS, file of 2026-04-10 | |
| Somaly Sith | Kennesaw, GA | 15 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61L | Methods or apparatus for sterilising materials or objects in general; disinfection, sterilisation or deodorisation of air; chemical aspects of bandages, dressings, absorbent pads or surgical articles; materials for bandages, dressings, absorbent pads or surgical articles | A61L27/50 | PVGPATDIS, file of 2026-04-10 |
| A61B | Diagnosis; surgery; identification | A61B2017/00884 | PVGPATDIS, file of 2026-04-10 |
| A61F | Filters implantable into blood vessels; prostheses; devices providing patency to, or preventing collapsing of, tubular structures of the body, e.g. stents; orthopaedic, nursing or contraceptive devices; fomentation; treatment or protection of eyes or ears; bandages, dressings or absorbent pads; first-aid kits | A61F2002/009 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-02-05 | Release of security interest Release of security interest | HAYFIN SERVICES LLP signed 2024-01-19 | MIMEDX GROUP, INC. MARIETTA, GA MIMEDX PROCESSING SERVICES, LLC MARIETTA, GA | 66493/322 | PASDL, file of 2026-10-15 |
| 2024-01-25 | Security interest Security interest Security interest | MIMEDX GROUP, INC. signed 2024-01-19 | CITIZENS BANK, N.A. PROVIDENCE, RI | 66371/136 | PASDL, file of 2026-10-15 |
| 2020-07-02 | Release of security interest Release of security interest | BLUE TORCH FINANCE LLC, AS COLLATERAL AGENT signed 2020-07-02 | MIMEDX GROUP, INC. MARIETTA, GA MIMEDX PROCESSING SERVICES, LLC MARIETTA, GA | 54075/687 | PASDL, file of 2026-10-15 |
| 2020-07-02 | Security interest Security interest Patent security agreement | MIMEDX GROUP, INC. signed 2020-07-02 MIMEDX PROCESSING SERVICES, LLC signed 2020-07-02 | HAYFIN SERVICES LLP, AS COLLATERAL AGENT LONDON | 53121/833 | PASDL, file of 2026-10-15 |
| 2019-06-11 | Security interest Security interest Security interest | MIMEDX GROUP, INC. signed 2019-06-10 | BLUE TORCH FINANCE LLC, AS COLLATERAL AGENT NEW YORK, NY | 49426/863 | PASDL, file of 2026-10-15 |
| 2019-01-24 | Release of security interest Termination and release of security interest in patents | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT signed 2019-01-23 | MIMEDX GROUP, INC. MARIETTA, GA | 48121/835 | PASDL, file of 2026-10-15 |
| 2015-10-15 | Security interest Security interest Notice of grant of security interest in patents | MIMEDX GROUP, INC. signed 2015-10-12 | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT CHARLOTTE, NC | 36872/498 | PASDL, file of 2026-10-15 |
| 2014-02-07 | Correction Corrective assignment to correct the street address of the receiving party: 60 chastain center boulevard should read 60 chastain center boulevard, "suite 60" previously recorded on reel 032076 frame 0842. assignor(s) hereby confirms the assigne | DANIEL, JOHN signed 2013-11-22 | MIMEDX GROUP, INC. KENNESAW, GA | 32172/567 | ECORSEXC, file of 2026-09-25 |
| 2014-01-29 | Assignment Assignment of assignor's interest | DANIEL, JOHN signed 2013-11-22 | MIMEDX GROUP, INC. KENNESAW, GA | 32076/842 | ECORSEXC, file of 2026-09-25 |
| 2013-09-23 | Assignment Assignment of assignor's interest | SITH, SOMALY signed 2013-09-09 | MIMEDX GROUP, INC. KENNESAW, GA | 31261/716 | ECORSEXC, file of 2026-09-25 |
| 2013-09-05 | Assignment Assignment of assignor's interest | KOOB, THOMAS J. signed 2013-07-19 SPENCER, RANDALL signed 2013-07-19 MORSE, BRENDA signed 2013-08-28 | MIMEDX GROUP, INC. KENNESAW, GA | 31147/680 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.