Patents
US 11147854 B2: Peptides having immunomodulatory properties
- Granted
- 2021-10-19
- Filed
- 2019-08-07 application 16534672
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure provides novel peptides that having immunomodulatory activities in vitro and in vivo. The peptides can include a particular striapathic region of alternating hydrophilic and hydrophobic modules that can adopt an amphipathic conformation under physiological conditions. This disclosure provides peptides that can specifically bind to key functional regions on one or more signaling proteins, particularly pro-inflammatory cytokines, macrophage inhibition proteins, and histone regulation proteins. This disclosure includes peptides that are sufficiently stable in the circulation to allow for intravenous administration. Pharmaceutical compositions including the subject peptides are also provided. The subject peptides find use in methods of modulating macrophage activity. In some cases, the peptide is a CD206-binding agent. Also provided are methods of treating a subject for a condition associated with chronic inflammation using the peptides and compositions of this disclosure.
Source: PVGPATDIS, file of 2026-04-10 (ipg211019.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Riptide Bioscience, Inc. 9 patents | US company or organization | Vallejo, CA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Jesse M. Jaynes | Auburn, AL | 21 | PVGPATDIS, file of 2026-04-10 | |
| Henry Wilfred Lopez | Napa, CA | 9 | PVGPATDIS, file of 2026-04-10 | |
| George R. Martin | Rockville, MD | 21 | PVGPATDIS, file of 2026-04-10 | |
| Clayton Yates | Auburn, AL | 7 | PVGPATDIS, file of 2026-04-10 | |
| Charles Garvin | Redwood City, CA | 4 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K38/08 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P29/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2019-12-17 | Assignment Assignment of assignor's interest | GARVIN, CHARLES signed 2019-01-12 LOPEZ, HENRY WILFRED signed 2019-01-14 YATES, CLAYTON signed 2019-02-04 JAYNES, JESSE signed 2019-08-26 MARTIN, GEORGE R. signed 2019-11-01 | RIPTIDE BIOSCIENCE, INC. VALLEJO, CA | 51304/421 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.