Patents
US 10751412 B2: Combination of a PD-1 antagonist and CPG-C type oligonucleotide for treating cancer
- Granted
- 2020-08-25
- Filed
- 2016-05-26 application 15577369
- Type
- Utility · 28 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure describes combination therapies comprising an antagonist of Programmed Death 1 receptor (PD-1) and a Toll-like receptor 9 (TLR9) agonist that is a CpG-C type oligonucleotide, and the use of the combination therapies for the treatment of cancer.
Source: PVGPATDIS, file of 2026-04-10 (ipg200825.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Merck Sharp & Dohme LLC 1,935 patents | US company or organization | Rahway, NJ | MERCK SHARP & DOHME CORP. SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PVGPATDIS, file of 2026-04-10 |
| DYNAVAX TECHNOLOGIES CORPORATION 50 patents | US company or organization | Emeryville, CA | DYNAVAX TECHNOLOGIES CORP SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Ying Yu | Palo Alto, CA | 12 | PVGPATDIS, file of 2026-04-10 | |
| Andrew Denker | Lansdowne, PA | 8 | PVGPATDIS, file of 2026-04-10 | |
| Svetlana Sadekova | Palo Alto, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Uyen Phan | Palo Alto, CA | 9 | PVGPATDIS, file of 2026-04-10 | |
| Robert A. Kastelein | Palo Alto, CA | 43 | PVGPATDIS, file of 2026-04-10 | |
| David KAUFMAN | North Wales, PA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Robert L. Coffman | Berkeley, CA | 23 | PVGPATDIS, file of 2026-04-10 | |
| Cristiana Guiducci | Berkeley, CA | 14 | PVGPATDIS, file of 2026-04-10 | |
| Robert Janssen | Berkeley, CA | 9 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/395 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K14/435 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2024-04-30 | Security interest Security interest Security interest | TRISALUS LIFE SCIENCES, INC. signed 2024-04-30 | ORBIMED ROYALTY & CREDIT OPPORTUNITIES IV, LP NEW YORK, NY | 67274/733 | PASDL, file of 2026-10-15 |
| 2023-01-03 | Merger Merger | MERCK SHARP & DOHME CORP. signed 2022-04-07 | MERCK SHARP & DOHME LLC RAHWAY, NJ | 62264/846 | ECORSEXC, file of 2026-09-25 |
| 2021-10-27 | Name change Change of name | SUREFIRE MEDICAL, INC. D/B/A TRISALUS LIFE SCIENCES signed 2021-09-29 | TRISALUS LIFE SCIENCES, INC. WESTMINSTER, CO | 57943/686 | ECORSEXC, file of 2026-09-25 |
| 2020-10-14 | Assignment Assignment of assignor's interest | DYNAVAX TECHNOLOGIES CORPORATION signed 2020-07-31 | SUREFIRE MEDICAL, INC. D/B/A TRISALUS LIFE SCIENCES WESTMINSTER, CO | 54057/158 | ECORSEXC, file of 2026-09-25 |
| 2018-06-08 | Assignment Assignment of assignor's interest | KAUFMAN, DAVID ROSS signed 2016-05-17 DENKER, ANDREW EVAN signed 2016-05-20 KASTELEIN, ROBERT A. signed 2016-05-23 PHAN, UYEN TRUONG signed 2016-05-23 SADEKOVA, SVETLANA signed 2016-05-23 YU, YING signed 2016-05-23 COFFMAN, ROBERT L. signed 2018-05-31 GUIDUCCI, CRISTIANA signed 2018-05-31 JANSSEN, ROBERT S. signed 2018-05-31 | MERCK SHARP & DOHME CORP. RAHWAY, NJ DYNAVAX TECHNOLOGIES CORPORATION BERKELEY, CA | 46328/7 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.