Patents
US 10722591 B2: Cleavable conjugates of TLR7/8 agonist compounds, methods for preparation, and uses thereof
- Granted
- 2020-07-28
- Filed
- 2018-11-13 application 16190010
- Type
- Utility · 121 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present disclosure relates to cleavable conjugates (for example, particle-based or antibody-based conjugates) of TLR7/8 agonists (for example, 1H-imidazo[4,5-c]quinoline derivatives) containing a conjugation linker, a cleavable linker, and a self-eliminating linker. The present disclosure also related to methods for preparation of the cleavable conjugates, uses thereof for stimulating an effective immune response, and uses thereof for the treatment of cancer.
Source: PVGPATDIS, file of 2026-04-10 (ipg200728.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| DYNAVAX TECHNOLOGIES CORPORATION 50 patents | US company or organization | Emeryville, CA | DYNAVAX TECHNOLOGIES CORP SEC filer FUZZY low confidence: same name (legal endings aside), one of each nationally | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Robert L. Coffman | Portola Valley, CA | 23 | PVGPATDIS, file of 2026-04-10 | |
| Stewart Chipman | Bainbridge Island, WA | 6 | PVGPATDIS, file of 2026-04-10 | |
| Radwan Kiwan | Richmond, CA | 8 | PVGPATDIS, file of 2026-04-10 | |
| Samuel Zalipsky | Redwood City, CA | 5 | PVGPATDIS, file of 2026-04-10 | |
| Gary S. Ott | Oakland, CA | 8 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/65 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
| C07D | Heterocyclic compounds | C07D471/04 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2018-12-04 | Assignment Assignment of assignor's interest | CHIPMAN, STEWART D. signed 2018-11-16 KIWAN, RADWAN signed 2018-11-16 OTT, GARY S. signed 2018-11-16 ZALIPSKY, SAMUEL signed 2018-11-18 COFFMAN, ROBERT L. signed 2018-11-28 | DYNAVAX TECHNOLOGIES CORPORATION BERKELEY, CA | 47673/12 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.