Patents
US 10688166 B2: Compositions and methods for improved car-T cell therapies
- Granted
- 2020-06-23
- Filed
- 2015-11-02 application 15524233
- Type
- Utility · 39 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention relates to the preparation and use in recipients of CAR-T cell-derived effector cells which are modified to limit their proliferation within the recipient. This is accomplished through the introduction of adducts into the nucleic acids of CAR-T cell-derived effector cells following expansion in vitro to provide expanded and activated CAR-T cell-derived effector cells that retain immunologic function, including the expression of one ore more cytokines.
Source: PVGPATDIS, file of 2026-04-10 (ipg200623.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Cerus Corporation 22 patents | US company or organization | Concord, CA | CERUS CORPORATION Federal lobbying client EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Adonis Stassinopoulos | Dublin, CA | 7 | PVGPATDIS, file of 2026-04-10 | |
| William GREENMAN | Lafayette, CA | 1 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K9/0019 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P35/00 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K14/7051 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0636 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-05-20 | Release of security interest Release of security interest | MIDCAP FINANCIAL TRUST signed 2026-05-20 | CERUS CORPORATION CONCORD, CA | 75610/621 | PASDL, file of 2026-08-13 |
| 2026-05-20 | Release of security interest Release of security interest | MIDCAP FUNDING IV TRUST signed 2026-05-20 | CERUS CORPORATION CONCORD, CA | 75583/598 | PASDL, file of 2026-08-13 |
| 2025-08-29 | Security interest Security interest Amended and restated intellectual property security agreement (term loan) | CERUS CORPORATION signed 2023-03-31 | MIDCAP FINANCIAL TRUST BETHESDA, MD | 72727/928 | PASDL, file of 2026-10-15 |
| 2025-08-29 | Security interest Security interest Amended and restated intellectual property security agreement (revolving loan) | CERUS CORPORATION signed 2023-03-31 | MIDCAP FUNDING IV TRUST BETHESDA, MD | 72727/854 | PASDL, file of 2026-10-15 |
| 2018-04-30 | Assignment Assignment of assignor's interest | GREENMAN, WILLIAM MARINER signed 2017-12-08 STASSINOPOULOS, ADONIS signed 2017-12-08 | CERUS CORPORATION CONCORD, CA | 45674/56 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.