Patents
US 10668104 B2: Brown adipocyte modification
- Granted
- 2020-06-02
- Filed
- 2016-06-07 application 15175777
- Type
- Utility · 7 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Methods and therapeutics are provided for treating metabolic disorders by increasing activation of brown adipose tissue. Generally, the methods and therapeutics can increase activation of brown adipose tissue to increase energy expenditure and induce weight loss. In one embodiment, a method for increasing activation of brown adipose tissue includes modifying brown adipocytes to express a gene that activates brown adipocytes, such as uncoupling protein 1. In another embodiment, a method for increasing brown adipose tissue activation includes increasing the number of brown adipocytes. This can be accomplished by inducing proliferation of adipocytes in vivo or expanding adipocytes ex vivo, transplanting adipocytes into brown adipose tissue depots or elsewhere and inducing differentiation of adipocyte progenitor cells, such as MSCs, adipocyte progenitor cells, pre-adipocytes and adipocyte precursor cells.
Source: PVGPATDIS, file of 2026-04-10 (ipg200602.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Ethicon Endo-Surgery, Inc. 1,347 patents | US company or organization | Cincinnati, OH | ETHICON ENDO-SURGERY. INC. State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
| The General Hospital Corporation 1,995 patents | US company or organization | Boston, MA | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Lee M. Kaplan | Wellesley, MA | 19 | PVGPATDIS, file of 2026-04-10 | |
| Nicholas Stylopoulos | Swampscott, MA | 11 | PVGPATDIS, file of 2026-04-10 | |
| Jason L. Harris | Lebanon, OH | 1286 | PVGPATDIS, file of 2026-04-10 | |
| Dwight Henninger | Waynesville, OH | 5 | PVGPATDIS, file of 2026-04-10 | |
| Taylor W. Aronhalt | Loveland, OH | 229 | PVGPATDIS, file of 2026-04-10 | |
| James W. Voegele | Cincinnati, OH | 67 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K35/35 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K14/47 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0653 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
No recorded assignments or security interests on file for this patent.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.