Patents
US 10660965 B2: Methods of enhancing drug delivery and effectiveness of therapeutic agents
- Granted
- 2020-05-26
- Filed
- 2011-03-28 application 13073861
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention in one aspect provides methods of enhancing uptake of a therapeutic agent in a target tissue as well as methods of treating a disease (such as cancer) or enhancing effectiveness of treatment with a therapeutic agent in an individual by co-administering a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane with the therapeutic agent. The present invention in another aspect provides a method of treatment or a method of selecting patients for treatment of a disease (such as cancer) with the combination of a therapeutic agent and a composition comprising nanoparticles comprising albumin and a poorly water soluble drug such as a taxane based on one or more characteristics of the target tissue that correlates or indicates the capability of getting enhanced therapeutic agent uptake as a result of the co-administration of the taxane nanoparticle composition in the target tissue (referred to as “the drug uptake capability”). Also provided are pharmaceutical compositions, article of manufacture, and kits useful for methods described herein.
Source: PVGPATDIS, file of 2026-04-10 (ipg200526.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Abraxis BioScience, LLC 72 patents | US company or organization | Summit, NJ | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Neil P. Desai | Santa Monica, CA | 80 | PVGPATDIS, file of 2026-04-10 | |
| Patrick Soon-Shiong | Culver City, CA | 449 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/42 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/04 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2020-04-08 | Correction Corrective assignment to correct the receiving party name previously recorded at reel: 26704 frame: 210. assignor(s) hereby confirms the assignment. | SOON-SHIONG, PATRICK signed 2011-07-06 DESAI, NEIL P. signed 2011-07-25 | ABRAXIS BIOSCIENCE, LLC SUMMIT, NJ | 52347/498 | ECORSEXC, file of 2026-09-25 |
| 2011-08-04 | Assignment Assignment of assignor's interest | SOON-SHIONG, PATRICK signed 2011-07-06 DESAI, NEIL P. signed 2011-07-25 | ABRAXIS BIOSCIENCE, LLP LOS ANGELES, CA | 26704/210 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.