Patents
US 10597428 B2: Compositions relating to a mutant clostridium difficile toxin and methods thereof
- Granted
- 2020-03-24
- Filed
- 2019-03-20 application 16359267
- Type
- Utility · 20 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
In one aspect, the invention relates to an immunogenic composition that includes a mutant Clostridium difficile toxin A and/or a mutant Clostridium difficile toxin B. Each mutant toxin includes a glucosyltransferase domain having at least one mutation and a cysteine protease domain having at least one mutation, relative to the corresponding wild-type C. difficile toxin. The mutant toxins may further include at least one amino acid that is chemically crosslinked. In another aspect, the invention relates to antibodies or binding fragments thereof that binds to said immunogenic compositions. In further aspects, the invention relates to isolated nucleotide sequences that encode any of the foregoing, and methods of use of any of the foregoing compositions.
Source: PVGPATDIS, file of 2026-04-10 (ipg200324.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Wyeth, LLC 476 patents | US company or organization | New York, NY | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Kathrin Ute Jansen | New York, NY | 58 | PVGPATDIS, file of 2026-04-10 | |
| Annaliesa Sybil Anderson | Upper Saddle River, NJ | 59 | PVGPATDIS, file of 2026-04-10 | |
| Robert G. K. Donald | South Orange, NJ | 21 | PVGPATDIS, file of 2026-04-10 | |
| Maninder K. Sidhu | New City, NY | 15 | PVGPATDIS, file of 2026-04-10 | |
| Narender Kumar Kalyan | Ridgewood, NJ | 14 | PVGPATDIS, file of 2026-04-10 | |
| Justin Keith Moran | West Nyack, NY | 36 | PVGPATDIS, file of 2026-04-10 | |
| Mark Edward Ruppen | Garnerville, NY | 45 | PVGPATDIS, file of 2026-04-10 | |
| Michael James Flint | Decatur, GA | 16 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/33 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/08 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P1/00 | PVGPATDIS, file of 2026-04-10 |
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N9/1051 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2023-03-27 | Correction Assignee address correction | WYETH LLC signed 2023-03-07 | WYETH LLC NEW YORK, NY | 63165/455 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.