Patents
US 10564159 B2: Sensitive and rapid methods of using chimeric receptors to identify autoimmune disease and assess disease severity
- Granted
- 2020-02-18
- Filed
- 2017-09-26 application 15715703
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The present invention provides methods and compositions useful in the diagnosis and management of autoimmune diseases. In particular, the present invention provides improved methods and compositions for the diagnosis and management of Graves' disease. The methods of the present invention not only avoids the need for radioactivity and are much simpler, economical, and rapid than methods traditionally used for the diagnosis of Graves' disease, but also improve upon the sensitivity and detection abilities of previous luciferase-based autoantibody detection assays. Such improvements are based upon the superior performance of assays comprising a chimeric TSH receptor in the presence of a glucocorticoid including, but not limited to, dexamethasone.
Source: PVGPATDIS, file of 2026-04-10 (ipg200218.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Diagnostic Hybrids, Inc. 13 patents | US company or organization | Athens, OH | DIAGNOSTIC HYBRIDS, INC. State business registration EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Leonard Kohn | Woodville, OH | 4 | PVGPATDIS, file of 2026-04-10 | |
| James L. Brown | Athens, OH | 12 | PVGPATDIS, file of 2026-04-10 | |
| David R. Scholl | Athens, OH | 9 | Person page FUZZY medium confidence | PVGPATDIS, file of 2026-04-10 |
| Yunsheng Li | Athens, OH | 14 | PVGPATDIS, file of 2026-04-10 | |
| Giorgio Napolitano | Pescara, IT | 4 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C12N | Microorganisms or enzymes; compositions thereof; propagating, preserving, or maintaining microorganisms; mutation or genetic engineering; culture media | C12N5/0602 | PVGPATDIS, file of 2026-04-10 |
| C07K | Peptides | C07K14/72 | PVGPATDIS, file of 2026-04-10 |
| G01N | Investigating or analysing materials by determining their chemical or physical properties | G01N33/566 | PVGPATDIS, file of 2026-04-10 |
| C12Q | Measuring or testing processes involving enzymes, nucleic acids or microorganisms ; compositions or test papers therefor; processes of preparing such compositions; condition-responsive control in microbiological or enzymological processes | C12Q1/6883 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2022-05-31 | Release of security interest Release of security interest | BANK OF AMERICA, N.A. signed 2022-05-27 | DIAGNOSTIC HYBRIDS, INC. ATHENS, OH | 60053/211 | ECORSEXC, file of 2026-09-25 |
| 2018-08-31 | Security interest Security interest Security interest | DIAGNOSTIC HYBRIDS, INC. signed 2018-08-31 | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT CHARLOTTE, NC | 46767/806 | ECORSEXC, file of 2026-09-25 |
| 2017-10-27 | Assignment Assignment of assignor's interest | NAPOLITANO, GIORGIO signed 2009-07-21 BROWN, JIM signed 2009-07-27 LI, YUNSHENG signed 2009-07-27 SCHOLL, DAVID signed 2009-07-28 KOHN, LEONARD signed 2009-07-31 | DIAGNOSTIC HYBRID, INC. ATHENS, OH | 43970/331 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.