Patents
US 10441661 B2: Benzoic acid, benzoic acid derivatives and heteroaryl carboxylic acid conjugates of hydromorphone, prodrugs, methods of making and use thereof
- Granted
- 2019-10-15
- Filed
- 2019-03-01 application 16290496
- Type
- Utility · 14 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The presently described technology provides compositions comprising aryl carboxylic acids chemically conjugated to hydromorphone (4,5-α-epoxy-3-hydroxy-17-methyl morphinan-6-one) to form novel prodrugs/compositions of hydromorphone. The hydromorphone prodrugs of the present technology have decreased side effects and decreased potential for abuse compared to unconjugated hydromorphone. The present technology also provides methods of treating patients, pharmaceutical kits and methods of synthesizing conjugates of the present technology.
Source: PVGPATDIS, file of 2026-04-10 (ipg191015.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| KEMPHARM, INC. 57 patents | US company or organization | Four Corners, FL | KEMPHARM, INC Form D issuer EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Travis Mickle | Kissimmee, FL | 83 | PVGPATDIS, file of 2026-04-10 | |
| Sven Guenther | Coralville, IA | 63 | PVGPATDIS, file of 2026-04-10 | |
| Guochen Chi | Coralville, IA | 41 | PVGPATDIS, file of 2026-04-10 | |
| Jaroslaw Kanski | Blacksburg, VA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Andrea K. Martin | Fincastle, VA | 30 | PVGPATDIS, file of 2026-04-10 | |
| Bindu Bera | Blacksburg, VA | 29 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K47/55 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P11/14 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2026-03-13 | Release of security interest Release of security interest | ALTER DOMUS (US) LLC signed 2026-03-12 | ZEVRA THERAPEUTICS, INC. CELEBRATION, FL | 75080/907 | PASDL, file of 2026-10-15 |
| 2024-04-08 | Security interest Security interest Security interest | ZEVRA THERAPEUTICS, INC. signed 2024-04-05 | ALTER DOMUS (US) LLC CHICAGO, IL | 67040/637 | PASDL, file of 2026-10-15 |
| 2024-02-23 | Name change Change of name | KEMPHARM, INC. signed 2023-02-21 | ZEVRA THERAPEUTICS, INC. CELEBRATION, FL | 66664/108 | PASDL, file of 2026-10-15 |
| 2019-05-22 | Assignment Assignment of assignor's interest | GUENTHER, SVEN signed 2017-09-19 MICKLE, TRAVIS signed 2017-09-19 BERA, BINDU signed 2017-09-20 KANSKI, JAROSLAW signed 2017-09-20 MARTIN, ANDREA K. signed 2017-09-20 CHI, GUOCHEN signed 2017-09-21 | KEMPHARM, INC. CELEBRATION, FL | 49257/696 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.