Patents
US 10149876 B2: Tripterygium wilfordii extracts to overcome chemotherapy resistance
- Granted
- 2018-12-11
- Filed
- 2013-08-19 application 14422216
- Type
- Utility · 5 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
The invention provides extracts and compositions derived from Tripterygium wilfordii for overcoming drug resistance in cancer therapy. This invention relates to organic solvent extracts of T. wilfordii and their use in cancer treatment, particularly in the treatment of cancers which have exhibited resistance to treatment by chemotherapeutic drugs. Methods of treating a cancer are disclosed. The method administers to a patient in need thereof a combination of (a) an organic solvent extract of T. wilfordii and (b) a chemotherapeutic drug. The organic solvent extract of T. wilfordii (a) and chemotherapeutic drug (b) are administered in a combined amount effective to treat the cancer. The cancer being treated is at least in part resistant to treatment by the chemotherapeutic drug (b) alone. Also disclosed are chemotherapeutic compositions comprising a combination of (a) an organic solvent extract of T. wilfordii and (b) a chemotherapeutic drug, wherein (a) and (b) are administered in a combined amount effective to treat the cancer; and a pharmaceutically acceptable carrier.
Source: PVGPATDIS, file of 2026-04-10 (ipg181211.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| WESTERN UNIVERSITY OF HEALTH SCIENCES 19 patents | US company or organization | Pomona, CA | WESTERN UNIVERSITY OF HEALTH SCIENCES State business registration EXACT high confidence: identical full name and state Western University of Health Sciences College or university EXACT high confidence: identical full name and state WESTERN UNIVERSITY OF HEALTH SCIENCES Nonprofit EXACT high confidence: identical full name and state | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Moses Sing Sum Chow | Chino Hills, CA | 2 | PVGPATDIS, file of 2026-04-10 | |
| Ying Huang | Arcadia, CA | 3 | PVGPATDIS, file of 2026-04-10 | |
| Jinghua Wang | Arcadia, CA | 31 | PVGPATDIS, file of 2026-04-10 | |
| Ranadheer Ravula | Atlanta, GA | 1 | PVGPATDIS, file of 2026-04-10 | |
| Zhi Jun Wang | Chino Hills, CA | 26 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| A61K | Preparations for medical, dental or toiletry purposes | A61K36/37 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P29/00 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2015-07-17 | Assignment Assignment of assignor's interest | RAVULA, RANADHEER signed 2014-08-04 CHOW, MOSES SING SUM signed 2014-08-06 WANG, ZHI JUN signed 2014-08-06 HUANG, YING signed 2014-08-07 WANG, JINGHUA JEFFREY signed 2014-08-07 | WESTERN UNIVERSITY OF HEALTH SCIENCES POMONA, CA | 36124/98 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.