Patents
US 10017480 B2: Compounds having a selective PDE4D inhibiting activity
- Granted
- 2018-07-10
- Filed
- 2015-02-10 application 15119034
- Type
- Utility · 12 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Compounds of formula (I), wherein Z=cyclopentyl. cyclopropylmethyl, —CH3; R′═—CH3, CHF2, X=formula (II) (III) (IV) (V) Y=—CO; —C═O(CH2), —CH(OH)—CH2, —CH2—C═O, —CH2—CH2—C═O; —CH2—CH(OH)—CH2, —CH2—CH(OCOR1)—CH2 NR2═ —N(CH2—CH2OH)2, formula (VI) (VII) (VIII) (IX) (X) (XI) R1=optionally substituted C1-C8 alkyl, optionally substituted aryl; optionally substituted aralkyl, preferably C1-C3 alkyl, more preferably CH3; and enantiomers, diastereoisomers and pharmaceutically acceptable salts thereof; these compounds have a PDE4D inhibiting activity and can be used as a medicament for treating dementia, in particular Alzheimer disease, and for improving memory.
Source: PVGPATDIS, file of 2026-04-10 (ipg180710.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Università Degli Studi Di Genova 23 patents | Foreign company or organization | Genova, IT | PVGPATDIS, file of 2026-04-10 | |
| COLUMBIA UNIVERSITY 26 patents | US company or organization | New York, NY | TRUSTEES OF COLUMBIA UNIVERSITY Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| Maastricht University 7 patents | Foreign company or organization | Eijsden, NL | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| Olga Bruno | Genova, IT | 2 | PVGPATDIS, file of 2026-04-10 | |
| Chiara Brullo | Genova, IT | 1 | PVGPATDIS, file of 2026-04-10 | |
| Alessia Romussi | Genova, IT | 4 | PVGPATDIS, file of 2026-04-10 | |
| Ernesto Fedele | Genova, IT | 1 | PVGPATDIS, file of 2026-04-10 | |
| Roberta Ricciarelli | Genova, IT | 1 | PVGPATDIS, file of 2026-04-10 | |
| Ottavio Arancio | New York, NY | 21 | PVGPATDIS, file of 2026-04-10 | |
| Jos Prickaerts | Eijsden, NL | 2 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07D | Heterocyclic compounds | C07D261/04 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P25/28 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2018-06-11 | Assignment Assignment of assignor's interest | RICCIARELLI, ROBERTA signed 2016-09-28 BRULLO, CHIARA signed 2016-09-29 BRUNO, OLGA signed 2016-09-29 FEDELE, ERNESTO signed 2016-09-29 ROMUSSI, ALESSIA signed 2016-09-30 PRICKAERTS, JOS signed 2016-10-26 ARANCIO, OTTAVIO signed 2017-06-05 | THE TRUSTEES OF COLUMBIA UNIVERSITY NEW YORK, NY MAASTRICHT UNIVERSITY MAASTRICHT UNIVERSITA DEGLI STUDI DI GENOVA GENOVA | 46332/676 | ECORSEXC, file of 2026-09-25 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.