Patents
US 9926346 B2: Recombinant mycobacterium encoding a heparin-binding hemagglutinin (HBHA) fusion protein and uses thereof
- Granted
- 2018-03-27
- Filed
- 2012-04-16 application 14394689
- Type
- Utility · 17 claims
- Elsewhere
- Google Patents ↗ · USPTO patent document ↗ · USPTO Patent Center record ↗
Abstract
Recombinant Mycobacteria (rMyc) which contain sequences encoding a heparin-binding hemagglutinin (HBHA) fusion protein are provided, as are methods of making and using the rMyc and the fusion protein. The fusion protein includes an amino terminal mycobacterial antigen Ag85B leader peptide and transcription of the fusion protein is driven by an Ag85B promoter sequence. The recombinant fusion protein is produced in abundance by the rMyc, is post-translationally methylated, and is highly antigenic.
Source: PVGPATDIS, file of 2026-04-10 (ipg180327.xml).
Assignees
| Assignee | Type | Place | Also on furp.org | Source |
|---|---|---|---|---|
| Aeras, LLC 2 patents | US company or organization | Rockville, MD | AERAS Nonprofit FUZZY medium confidence: same name (governing-board words and legal endings aside) and state | PVGPATDIS, file of 2026-04-10 |
| Institut National De La Sante Et De La Recherche Medicale (Inserm) 745 patents | Foreign company or organization | Paris, FR | PVGPATDIS, file of 2026-04-10 |
Inventors
| Inventor | Place | Patents | Person page | Source |
|---|---|---|---|---|
| John Fulkerson | Silver Spring, MD | 8 | PVGPATDIS, file of 2026-04-10 | |
| Michael Brennan | Rockville, MD | 3 | PVGPATDIS, file of 2026-04-10 | |
| Kamalakannan Velmurugan | Rockville, MD | 1 | PVGPATDIS, file of 2026-04-10 | |
| Camille Locht | Brussels, BE | 26 | PVGPATDIS, file of 2026-04-10 |
CPC categories
| Subclass | Category | First group | Source |
|---|---|---|---|
| C07K | Peptides | C07K14/35 | PVGPATDIS, file of 2026-04-10 |
| A61K | Preparations for medical, dental or toiletry purposes | A61K39/04 | PVGPATDIS, file of 2026-04-10 |
| A61P | Specific therapeutic activity of chemical compounds or medicinal preparations | A61P31/06 | PVGPATDIS, file of 2026-04-10 |
Cooperative Patent Classification, as currently assigned (one row per subclass).
Assignments and security interests
| Recorded | What | From | To | Reel/frame | Source |
|---|---|---|---|---|---|
| 2017-07-20 | Assignment Assignment of assignor's interest | LOCHT, CAMILLE signed 2017-05-23 | INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE (INSERM) PARIS | 43051/533 | ECORSEXC, file of 2026-09-25 |
| 2017-07-20 | Assignment Assignment of assignor's interest | BRENNAN, MICHAEL signed 2017-05-11 VELMURUGAN, KAMALAKANNAN signed 2017-06-07 FULKERSON, JOHN signed 2017-06-12 | AERAS GLOBAL TB VACCINE FOUNDATION ROCKVILLE, MD | 43051/184 | ECORSEXC, file of 2026-09-25 |
| 2016-12-27 | Name change Change of name | AERAS GLOBAL TB VACCINE FOUNDATION signed 2011-03-10 | AERAS ROCKVILLE, MD | 41303/681 | PASDL, file of 2026-10-15 |
Documents recorded with the USPTO Assignment Recordation Branch that list this patent. A security interest is a lender’s claim on the patent as collateral; a release ends it.
USPTO bulk data: PatentsView granted patents, disambiguated (PVGPATDIS) for patents, assignees, inventors, places and CPC categories; the USPTO Patent Assignment Dataset (ECORSEXC) for assignments and security interests. Patents filed in the last 20 years. No claims or full text. Links to other records are by name (and state): EXACT means the identical full name and state; FUZZY means a looser name match, with the confidence shown.